Conventional nucleic acid detection technologies usually rely on amplification to improve
sensitivity, which has drawbacks, such as amplification bias, complicated operation, high …

RNA-binding proteins (RBPs) are crucial regulators of gene expression, often composed of
defined domains interspersed with flexible, intrinsically disordered regions. Determining the …

The 5′ untranslated region (UTR) of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) genome is a conserved, functional and structured genomic region consisting …

The outbreak of COVID‐19 in December 2019 required the formation of international
consortia for a coordinated scientific effort to understand and combat the virus. In this …

2D NOESY and TOCSY play central roles in contemporary NMR. We have recently
discussed how solvent-driven exchanges can significantly enhance the sensitivity of such …

Ultra-sensitive nucleic acid detection is important for rapid prevention of infectious diseases.
Recently, clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR …

Magnetization transfer experiments are versatile nuclear magnetic resonance (NMR) tools
providing site-specific information. We have recently discussed how saturation …

Overcoming line broadening of labile protons and achieving high‐resolution NMR spectra is
crucial for the structural and conformational analysis of organic molecules. Recently, Ma et …

NMR spectroscopy serves as an immensely powerful tool for component assignments and
molecular structure elucidations. However, proton NMR spectra are generally trapped with …

INEPT-and HMQC-based pulse sequences are widely used to transfer polarization between
heteronuclei, particularly in biomolecular spectroscopy: they are easy to setup and involve …