RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …

The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …

Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …

R-loops are three-stranded nucleic acid structures that are abundant and widespread across
the genome and that have important physiological roles in many nuclear processes. Their …

R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …

During transcription, the nascent RNA strand can base pair with its template DNA, displacing
the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are …

DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent
non-scheduled co-transcriptional structures with a negative impact on transcription …

Alternative lengthening of telomeres (ALT), a telomerase-independent process maintaining
telomeres, is mediated by break-induced replication (BIR). RAD52 promotes ALT by …

R-loops are non-B DNA structures with intriguing dual consequences for gene expression
and genome stability. In addition to their recognized roles in triggering DNA double-strand …

Homologous recombination (HR) repairs DNA double-strand breaks (DSBs) in the S and G2
phases of the cell cycle,–. Several HR proteins are preferentially recruited to DSBs at …