Tumor-targeting peptides: ligands for molecular imaging and therapy
N Zhao, Y Qin, H Liu, Z Cheng - Anti-Cancer Agents in …, 2018 - ingentaconnect.com
The aberrant proliferation of tumor cells and abundant vasculature in tumor tissues are
closely correlated with receptors that are specifically dysregulated in tumor cells. These …
closely correlated with receptors that are specifically dysregulated in tumor cells. These …
Multiplexed proteome dynamics profiling reveals mechanisms controlling protein homeostasis
MM Savitski, N Zinn, M Faelth-Savitski, D Poeckel… - Cell, 2018 - cell.com
Protein degradation plays important roles in biological processes and is tightly regulated.
Further, targeted proteolysis is an emerging research tool and therapeutic strategy …
Further, targeted proteolysis is an emerging research tool and therapeutic strategy …
Homing peptides for cancer therapy
P Lingasamy, T Teesalu - Bio-nanomedicine for cancer therapy, 2021 - Springer
Tumor-homing peptides are widely used for improving tumor selectivity of anticancer drugs
and imaging agents. The goal is to increase tumor uptake and reduce accumulation at …
and imaging agents. The goal is to increase tumor uptake and reduce accumulation at …
Solvent-induced protein precipitation for drug target discovery on the proteomic scale
X Zhang, Q Wang, Y Li, C Ruan, S Wang… - Analytical …, 2019 - ACS Publications
High-throughput drug discovery is highly dependent on the targets available to accelerate
the process of candidates screening. Traditional chemical proteomics approaches for the …
the process of candidates screening. Traditional chemical proteomics approaches for the …
In vivo conformational dynamics of Hsp90 and its interactors
Hsp90 belongs to a family of some of the most highly expressed heat shock proteins that
function as molecular chaperones to protect the proteome not only from the heat shock but …
function as molecular chaperones to protect the proteome not only from the heat shock but …
Discovery of a novel EGFR ligand DPBA that degrades EGFR and suppresses EGFR-positive NSCLC growth
Epidermal growth factor receptor (EGFR) activation plays a pivotal role in EGFR-driven non-
small cell lung cancer (NSCLC) and is considered as a key target of molecular targeted …
small cell lung cancer (NSCLC) and is considered as a key target of molecular targeted …
Development of Novel Silicon-Based Hydrophobic Tags (SiHyT) for Targeted Proteins Degradation
L Ma, K Zhang, Z Huang, Y Guo, N Liu… - Journal of Medicinal …, 2024 - ACS Publications
Recent advances in targeted protein degradation (TPD) have propelled it to the forefront of
small molecular drug discovery. Among these, hydrophobic tagging (HyT) strategies have …
small molecular drug discovery. Among these, hydrophobic tagging (HyT) strategies have …
EGFR targeted therapies and radiation: Optimizing efficacy by appropriate drug scheduling and patient selection
The epidermal growth factor receptor (EGFR) plays an important role in tumor progression
and treatment resistance for many types of malignancies including head and neck …
and treatment resistance for many types of malignancies including head and neck …
Mechanisms of resistance to EGFR tyrosine kinase inhibitors and therapeutic approaches: an update
A Ahsan - Lung Cancer and Personalized Medicine: Current …, 2016 - Springer
Resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in
non small cell lung cancer (NSCLC) is mediated by two major mechanisms namely …
non small cell lung cancer (NSCLC) is mediated by two major mechanisms namely …
Bacterial proteins and peptides in cancer therapy: today and tomorrow
AM Chakrabarty, N Bernardes, AM Fialho - Bioengineered, 2014 - Taylor & Francis
Cancer is one of the most deadly diseases worldwide. In the last three decades many efforts
have been made focused on understanding how cancer grows and responds to drugs. The …
have been made focused on understanding how cancer grows and responds to drugs. The …