There are 3 common physiological estrogens, of which estradiol (E2) is seen to decline
rapidly over the menopausal transition. This decline in E2 has been associated with a …

Muscarinic acetylcholine receptors (mAChR) play important roles in regulating complex
behaviors such as cognition, movement, and reward, making them ideally situated as …

Schizophrenia is a severe neuropsychiatric disorder characterized by a diverse range of
symptoms that can have profound impacts on the lives of patients. Currently available …

Schizophrenia is a major mental illness characterized by positive and negative symptoms,
and by cognitive deficit. Although cognitive impairment is disabling for patients, it has been …

Alzheimer's disease (AD) remains a major cause of morbidity and mortality worldwide, and
despite extensive research, only a few drugs are available for management of the disease …

Developing drugs for the central nervous system (CNS) requires fine chemical modifications,
as a strict balance between size and lipophilicity is necessary to improve the permeability …

The M1 muscarinic acetylcholine receptor (mAChR) plays a crucial role in learning and
memory processes and has long been identified as a promising therapeutic target for the …

Many dementias are propagated through the spread of “prion-like” misfolded proteins. This
includes prion diseases themselves (such as Creutzfeldt-Jakob disease) and Alzheimer's …

Cholinesterase inhibitors, the current frontline symptomatic treatment for Alzheimer's
disease (AD), are associated with low efficacy and adverse effects. M1 muscarinic …

Introduction Successful phase 3 trials of KarXT in people with schizophrenia herald a new
era of treating the disorder with drugs that do not target the dopamine D2 receptor. The …