Over the last five decades, a large body of evidence has accrued for structural and metabolic
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …

Diffusion MRI (dMRI) has proven to be a useful imaging approach for both clinical diagnosis
and research investigating the microstructures of nervous tissues, and it has helped us to …

We present distinct patterns of neurite distribution in the human cerebral cortex using
diffusion magnetic resonance imaging (MRI). We analyzed both high-resolution structural …

Psychotic disorders are mental illnesses characterized by difficulties in reality testing1.
Schizophrenia is a severe and chronic psychotic disorder with a life time prevalence of …

In Alzheimer's disease (AD), neurodegenerative processes are ongoing for years prior to the
time that cortical atrophy can be reliably detected using conventional neuroimaging …

Recent discovery of approximately 270 common genetic variants associated with
schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population …

Alzheimer's disease (AD) is associated with extensive alterations in grey matter
microstructure, but our ability to quantify this in vivo is limited. Neurite orientation dispersion …

While major psychiatric disorders lack signature diagnostic neuropathologies akin to
dementias, classic postmortem studies have established microstructural involvement, ie …

Understanding the neuropathological underpinnings of mental disorders such as
schizophrenia, major depression, and bipolar disorder is an essential step towards the …

Hippocampal subfields exhibit differential vulnerabilities to Alzheimer's disease-associated
pathology including abnormal accumulation of amyloid-β deposition and neurofibrillary …