The role of tricarboxylic acid cycle metabolites in viral infections

FJ Sánchez-García, CA Pérez-Hernández… - Frontiers in cellular …, 2021 - frontiersin.org
Host cell metabolism is essential for the viral replication cycle and, therefore, for productive
infection. Energy (ATP) is required for the receptor-mediated attachment of viral particles to …

Effects of metabolism on macrophage polarization under different disease backgrounds

JX Sun, XH Xu, L Jin - Frontiers in Immunology, 2022 - frontiersin.org
Macrophages are versatile immune cells associated with various diseases, and their
phenotypes and functions change on the basis of the surrounding environments …

Organoids transplantation attenuates intestinal ischemia/reperfusion injury in mice through L-Malic acid-mediated M2 macrophage polarization

FL Zhang, Z Hu, YF Wang, WJ Zhang, BW Zhou… - Nature …, 2023 - nature.com
Intestinal organoid transplantation is a promising therapy for the treatment of mucosal injury.
However, how the transplanted organoids regulate the immune microenvironment of …

Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells

T Ramalho, PA Assis, O Ojelabi, L Tan, B Carvalho… - Cell Metabolism, 2024 - cell.com
Severe forms of malaria are associated with systemic inflammation and host metabolism
disorders; however, the interplay between these outcomes is poorly understood. Using a …

San-Huang-Yi-Shen capsule ameliorates diabetic nephropathy in rats through modulating the gut microbiota and overall metabolism

X Su, W Yu, A Liu, C Wang, X Li, J Gao, X Liu… - Frontiers in …, 2022 - frontiersin.org
San-Huang-Yi-Shen capsule (SHYS) has been used in the treatment of diabetic
nephropathy (DN) in clinic. However, the mechanisms of SHYS on DN remain unknown. In …

C. elegans as a model to study mitochondrial biology and disease

T Onraet, S Zuryn - Seminars in Cell & Developmental Biology, 2024 - Elsevier
Mitochondria perform a myriad of essential functions that ensure organismal homeostasis,
including maintaining bioenergetic capacity, sensing and signalling the presence of …

Pi-Dan-Jian-Qing decoction ameliorates type 2 diabetes mellitus through regulating the gut microbiota and serum metabolism

X Xie, J Liao, Y Ai, J Gao, J Zhao, F Qu, C Xu… - Frontiers in Cellular …, 2021 - frontiersin.org
Pi-Dan-Jian-Qing decoction (PDJQ) can been used in the treatment of type 2 diabetes
mellitus (T2DM) in clinic. However, the protective mechanisms of PDJQ on T2DM remain …

[HTML][HTML] The role of metabolic reprogramming of tumor-associated macrophages in shaping the immunosuppressive tumor microenvironment

L Li, Y Tian - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Macrophages are potent immune effector cells in innate immunity and exert dual-effects in
the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) make up a …

[HTML][HTML] Metabolism shapes immune responses to Staphylococcus aureus

P Arumugam, T Kielian - Journal of Innate Immunity, 2024 - karger.com
Background: Staphylococcus aureus (S. aureus) is a common cause of hospital-and
community-acquired infections that can result in various clinical manifestations ranging from …

The dynamic change of flavor characteristics in Pacific oyster (Crassostrea gigas) during depuration uncovered by mass spectrometry-based metabolomics combined …

L Chen, X Teng, Y Liu, H Shi, Z Li, C Xue - Food Chemistry, 2024 - Elsevier
The flavor of Pacific oyster (Crassostrea gigas) significantly changed during the depuration
process. This work aimed to explore the mechanism of flavor changes during the 72 h …