Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …

Multidrug resistant Gram‐negative bacterial infections are on the rise, and there is a lack of
new classes of drugs to treat these pathogens. This drug shortage is largely due to the …

The spread of antimicrobial resistance has become a serious public health concern, making
once-treatable diseases deadly again and undermining the achievements of modern …

Fluoroquinolones remain one of the most important kind of antibacterial agents used
nowadays. The emergence of more virulent and resistant strains of bacteria by the …

We live in the era of antibiotic resistance, and this problem will progressively worsen if no
new solutions emerge. In particular, Gram-negative pathogens present both biological and …

The upsurge of multiple drug resistance (MDR) bacteria substantially diminishes the
effectiveness of antibiotic arsenal and therefore intensifies the rate of therapeutic failure. The …

The new fluoroquinolones (clinafloxacin, gatifloxacin, gemifloxacin, grepafloxacin,
levofloxacin, moxifloxacin, sitafloxacin, sparfloxacin and trovafloxacin) offer excellent activity …

Nanoparticle metal oxides offer a wide variety of potential applications in medicine due to
the unprecedented advances in nanobiotechnology research. In this work, the effect of zinc …

Bacterial multidrug resistance (MDR) efflux pumps are an important mechanism of antibiotic
resistance and are required for many pathogens to cause infection. They are also being …

Phenotypic variations between individual microbial cells play a key role in the resistance of
microbial pathogens to pharmacotherapies. Nevertheless, little is known about cell …