Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
adults over 50 years old. Genetic, epidemiological, and molecular studies are beginning to …

High-density lipoprotein (HDL) has been proposed to have several antiatherosclerotic
properties, including the ability to mediate macrophage cholesterol efflux, antioxidant …

Angiopoietin-like protein (ANGPTL) 3 regulates plasma lipids by inhibiting LPL and
endothelial lipase (EL). ANGPTL3 inactivation lowers LDL-C independently of the classical …

Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol
and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic …

The genetic basis of most traits is highly polygenic and dominated by non-coding alleles. It is
widely assumed that such alleles exert small regulatory effects on the expression of cis …

The metabolism of high-density lipoproteins (HDL), which are inversely related to risk of
atherosclerotic cardiovascular disease, involves a complex interplay of factors regulating …

More cardiovascular disease occurs in patients with either type 1 or 2 diabetes. The link
between diabetes and atherosclerosis is, however, not completely understood. Among the …

Atherosclerosis is a chronic inflammatory disease promoted by hyperlipidemia. Several
studies support FOXP3-positive regulatory T cells (Tregs) as inhibitors of atherosclerosis; …

High density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart
disease, and HDL exerts various potentially antiatherogenic properties, including the …

Research into lipoprotein metabolism has developed because understanding lipoprotein
metabolism has important clinical indications. Lipoproteins are risk factors for cardiovascular …