The protein-protein interaction underlying l&and recogmtion by CD2 must ensure sprcifuty
while allowing for wry weak binding. The CD5Rbmdmg site on human CD2 has nuw brrn …

Two signals are required for induction of cell proliferation and cytokine production in resting
T cells. Occupancy of the T cell receptor by antigen/MHC complexes delivers the first signal …

Gene expression profiles were examined in 33 adult patients with T-cell acute lymphocytic
leukemia (T-ALL). Nonspecific filtering criteria identified 313 genes differentially expressed …

Cadherins are calcium-dependent cell adhesion molecules containing extracellular repeats
of approximately 110 amino acids. The three-dimensional structure of the amino-terminal …

Objective Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually
arising on a background of chronic liver injury involving inflammatory and hepatic …

The adhesion domain of human CD2 bears a single N-linked carbohydrate. The solution
structure of a fragment of CD2 containing the covalently bound high-mannose N-glycan …

Interaction between CD2 and its counterreceptor, CD58 (LFA-3), on opposing cells
optimizes immune recognition, facilitating contacts between helper T lymphocytes and …

Innate lymphoid cells (ILC) are a heterogeneous group of cellular subsets that produce large
amounts of T cell–associated cytokines in response to innate stimulation in the absence of …

In the vertebrate immune system, each B-lymphocyte expresses a surface IgM-class B cell
receptor (BCR). When cross-linked by antigen or anti-IgM antibody, the BCR accumulates …

T cells respond to peptide antigen in association with MHC products on antigen-presenting
cells (APCs). A number of accessory or costimulatory molecules have been identified that …