Neurodegenerative disorders (NDs) affect essential functions not only in the CNS, but also
cause persistent gut dysfunctions, suggesting that they have an impact on both CNS and gut …

Frontotemporal dementia (FTD) is a neurodegenerative disease of growing interest, since it
accounts for up to 10% of middle-age-onset dementias and entails a social, economic, and …

The protein dyshomeostasis is identified as the hallmark of many age-related
neurodegenerative disorders including Parkinson's disease (PD). The diseased brain shows …

Neurodegenerative diseases, characterized by progressive loss in selected areas of the
nervous system, are becoming increasingly prevalent worldwide due to an aging population …

The impacts of menopause on neurodegenerative diseases, especially the changes in
steroid hormones, have been well described in cell models, animal models, and humans …

This review is focused on the mechanisms that regulate health, disease and aging redox
status, the signal pathways that counteract oxidative and reductive stress, the role of food …

Proteasome is the principal hydrolytic machinery responsible for the great majority of protein
degradation. The past three decades have testified prominent advances about proteasome …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that produces a
selective loss of the motor neurons of the spinal cord, brain stem and motor cortex. Oxidative …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
memory loss due to aberrant accumulation of misfolded proteins inside and outside neurons …

Molecular chaperones have a role to stabilize proteins or assist them in reaching their native
fold. Heat shock proteins (HSPs) are a family of molecular chaperons that protect proteins …