Transforming growth factor-β signaling: from tissue fibrosis to therapeutic opportunities

LL Ren, XJ Li, TT Duan, ZH Li, JZ Yang… - Chemico-biological …, 2023 - Elsevier
Fibrosis refers to the excessive deposition of extracellular matrix components in the
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in …

The role of macrophages in the development of acute and chronic inflammatory lung diseases

JW Lee, W Chun, HJ Lee, JH Min, SM Kim, JY Seo… - Cells, 2021 - mdpi.com
Macrophages play an important role in the innate and adaptive immune responses of organ
systems, including the lungs, to particles and pathogens. Cumulative results show that …

Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis

T Tsukui, PJ Wolters, D Sheppard - Nature, 2024 - nature.com
Fibroblasts are present throughout the body and function to maintain tissue homeostasis.
Recent studies have identified diverse fibroblast subsets in healthy and injured tissues,, but …

Small interfering RNA: Discovery, pharmacology and clinical development—An introductory review

P Ranasinghe, ML Addison, JW Dear… - British Journal of …, 2023 - Wiley Online Library
Post‐transcriptional gene silencing targets and degrades mRNA transcripts, silencing the
expression of specific genes. RNA interference technology, using synthetic structurally well …

The therapy of idiopathic pulmonary fibrosis: what is next?

V Somogyi, N Chaudhuri, SE Torrisi… - European …, 2019 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung
disease, characterised by progressive scarring of the lung and associated with a high …

Deep Generative Models in De Novo Drug Molecule Generation

C Pang, J Qiao, X Zeng, Q Zou… - Journal of Chemical …, 2023 - ACS Publications
The discovery of new drugs has important implications for human health. Traditional
methods for drug discovery rely on experiments to optimize the structure of lead molecules …

Targeting oxidative stress as a therapeutic approach for idiopathic pulmonary fibrosis

C Estornut, J Milara, MA Bayarri, N Belhadj… - Frontiers in …, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by an
abnormal reepithelialisation, an excessive tissue remodelling and a progressive fibrosis …

Stem cell therapy for COVID‐19, ARDS and pulmonary fibrosis

Z Li, S Niu, B Guo, T Gao, L Wang, Y Wang… - Cell …, 2020 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is an acute respiratory infectious disease
caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). COVID‐19 …

Sex and gender differences in lung disease

P Silveyra, N Fuentes, DE Rodriguez Bauza - Lung Inflammation in Health …, 2021 - Springer
Sex differences in the anatomy and physiology of the respiratory system have been widely
reported. These intrinsic sex differences have also been shown to modulate the …

Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis

YJ Nie, SH Wu, YH Xuan, G Yan - Military Medical Research, 2022 - Springer
Idiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease with no
established treatment and is characterized by progressive scarring of the lung tissue and an …