Lipids in atherosclerosis: pathophysiology and the role of calculated lipid indices in assessing cardiovascular risk in patients with hyperlipidemia

M Gaggini, F Gorini, C Vassalle - International journal of molecular …, 2022 - mdpi.com
The role of lipids is essential in any phase of the atherosclerotic process, which is
considered a chronic lipid-related and inflammatory condition. The traditional lipid profile …

[HTML][HTML] The role of lipids and lipoproteins in atherosclerosis

MRF Linton, PG Yancey, SS Davies, WG Jerome… - Endotext …, 2019 - ncbi.nlm.nih.gov
Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

Vitamin D and its role in the lipid metabolism and the development of atherosclerosis

AM Surdu, O Pînzariu, DM Ciobanu, AG Negru… - Biomedicines, 2021 - mdpi.com
Vitamin D, a crucial hormone in the homeostasis and metabolism of calcium bone, has lately
been found to produce effects on other physiological and pathological processes …

Immunobiology of atherosclerosis: a complex net of interactions

B Herrero-Fernandez, R Gomez-Bris… - International Journal of …, 2019 - mdpi.com
Cardiovascular disease is the leading cause of mortality worldwide, and atherosclerosis the
principal factor underlying cardiovascular events. Atherosclerosis is a chronic inflammatory …

Role of inflammatory cell subtypes in heart failure

D Strassheim, EC Dempsey… - Journal of …, 2019 - Wiley Online Library
Inflammation is a well‐known feature of heart failure. Studies have shown that while some
inflammation is required for repair during injury and is protective, prolonged inflammation …

T-cell recruitment to the heart: friendly guests or unwelcome visitors?

RM Blanton, FJ Carrillo-Salinas… - American Journal of …, 2019 - journals.physiology.org
Myocardial inflammation can lead to lethal acute or chronic heart failure (HF). T lymphocytes
(T cells), have been reported in the inflamed heart in different etiologies of HF, and more …

Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism

LM Tsujikawa, L Fu, S Das, C Halliday, BD Rakai… - Clinical …, 2019 - Springer
Abstract Background Apabetalone (RVX-208) is a bromodomain and extraterminal protein
inhibitor (BETi) that in phase II trials reduced the relative risk (RR) of major adverse cardiac …

Influence of arterial mechanical properties on carotid blood flow: Comparison of CFD and FSI studies

D Lopes, H Puga, JC Teixeira, SF Teixeira - International Journal of …, 2019 - Elsevier
Carotid artery blood flow is studied to compare models with rigid and elastic walls.
Considering a patient-specific geometry and transient boundary conditions. In the case of …

[HTML][HTML] Heart inflammation: immune cell roles and roads to the heart

FJ Carrillo-Salinas, N Ngwenyama… - The American journal of …, 2019 - Elsevier
Heart failure (HF) has been traditionally viewed as a disease of the cardiac muscle
associated with systemic inflammation. Burgeoning evidence implicates immune effector …

Aryl hydrocarbon receptor pathway: Role, regulation and intervention in atherosclerosis therapy

K Zhu, Q Meng, Z Zhang, T Yi… - Molecular …, 2019 - spandidos-publications.com
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor originally
isolated and characterized as the dioxin or xenobiotic receptor. With the discovery of …