The metabolic face of migraine—from pathophysiology to treatment

EC Gross, M Lisicki, D Fischer, PS Sándor… - Nature Reviews …, 2019 - nature.com
Migraine can be regarded as a conserved, adaptive response that occurs in genetically
predisposed individuals with a mismatch between the brain's energy reserve and workload …

Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges

M Arenas‐Jal, JM Suñé‐Negre… - … reviews in food …, 2020 - Wiley Online Library
World population growth and aging are posing unprecedented challenges in sustaining the
health of 9.1 billion people that will be occupying the planet by 2050. Although …

[HTML][HTML] The role of nutrients in the pathogenesis and treatment of migraine headaches

E Nattagh-Eshtivani, MA Sani, M Dahri… - Biomedicine & …, 2018 - Elsevier
Objective Migraine as a disabling neurovascular disease affects 6% of men and 18% of
women worldwide. The deficiency of many nutrients including magnesium, niacin, riboflavin …

Potential protective mechanisms of ketone bodies in migraine prevention

EC Gross, RJ Klement, J Schoenen, DP D'Agostino… - Nutrients, 2019 - mdpi.com
An increasing amount of evidence suggests that migraines are a response to a cerebral
energy deficiency or oxidative stress levels that exceed antioxidant capacity. The ketogenic …

Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine—a meta-analysis

S Sazali, S Badrin, MN Norhayati, NS Idris - BMJ open, 2021 - bmjopen.bmj.com
Objective To determine the effects of coenzyme Q10 (CoQ10) for reduction in the severity,
frequency of migraine attacks and duration of headache in adult patients with migraine …

Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine

EC Gross, N Putananickal, AL Orsini, DR Vogt… - Scientific Reports, 2021 - nature.com
Increasing evidence points towards the role of mitochondrial functioning, energy
metabolism, and oxidative stress in migraine. However not all previous research has been …

The association of dietary patterns with migraine attack frequency in migrainous women

S Hajjarzadeh, R Mahdavi, D Shalilahmadi… - Nutritional …, 2020 - Taylor & Francis
Objectives: Migraine is a debilitating neurovascular disorder. The relation of diets and
migraine is a controversial topic yet. This study assessed the association of dietary patterns …

Mapping assessments instruments for headache disorders against the ICF biopsychosocial model of health and disability

D D'Amico, SJ Tepper, E Guastafierro, C Toppo… - International Journal of …, 2021 - mdpi.com
Headache disorders have a strong impact on sufferers' lives. However, the “content” of
assessment instruments addressing concepts, such as disability and quality of life (QoL) …

Effect of coenzyme Q10 supplementation on clinical features of migraine: A systematic review and dose–response meta-analysis of randomized controlled trials

M Parohan, P Sarraf, MH Javanbakht… - Nutritional …, 2020 - Taylor & Francis
Objective: Coenzyme Q10 is an antioxidant and an essential mitochondrial cofactor which
has been suggested to improve the clinical features of migraine. Several randomized clinical …

Reduction in Migraine and Headache Frequency and Intensity With Combined Antioxidant Prophylaxis (N‐acetylcysteine, Vitamin E, and Vitamin C): A Randomized …

EJ Visser, PD Drummond, JLA Lee‐Visser - Pain Practice, 2020 - Wiley Online Library
Objective To investigate the preventive effects of a combined antioxidant drug (N‐
acetylcysteine, vitamin E, and vitamin C [NEC]) on migraine outcomes. Migraine is …