Background The recent development of single-cell transcriptomics has enabled gene
expression to be measured in individual cells instead of being population-averaged. Despite …

We present a theoretical framework to analyze the dynamics of gene expression with
stochastic bursts. Beginning with an individual-based model which fully accounts for the …

Here we investigate single-cell stochastic gene expression kinetics in a minimal coupled
gene circuit with positive-plus-negative feedback. A triphasic stochastic bifurcation is …

Dave Garbers' work significantly contributed to our understanding of sperm's regulated
motility, capacitation, and the acrosome reaction. These key sperm functions involve …

Pluripotent embryonic stem cells are of paramount importance for biomedical sciences
because of their innate ability for self-renewal and differentiation into all major cell lines. The …

Single-cell experiments show that gene expression is stochastic and bursty, a feature that
can emerge from slow switching between promoter states with different activities. In addition …

We study the stationary states of variants of the noisy voter model, subject to fluctuating
parameters or external environments. Specifically, we consider scenarios in which the …

Inside individual cells, expression of genes is stochastic across organisms ranging from
bacterial to human cells. A ubiquitous feature of stochastic expression is burst-like synthesis …

In biology phenotypic switching is a common bet-hedging strategy in the face of uncertain
environmental conditions. Existing mathematical models often focus on periodically …

Synthesis of gene products in bursts of multiple molecular copies is an important source of
gene expression variability. This paper studies large deviations in a Markovian drift-jump …