Cancer vaccines: Building a bridge over troubled waters
MLC Sellars, CJ Wu, EF Fritsch - Cell, 2022 - cell.com
Cancer vaccines aim to direct the immune system to eradicate cancer cells. Here we review
the essential immunologic concepts underpinning natural immunity and highlight the …
the essential immunologic concepts underpinning natural immunity and highlight the …
Clinical and molecular response to tebentafusp in previously treated patients with metastatic uveal melanoma: a phase 2 trial
In patients with previously treated metastatic uveal melanoma, the historical 1 year overall
survival rate is 37% with a median overall survival of 7.8 months. We conducted a …
survival rate is 37% with a median overall survival of 7.8 months. We conducted a …
A longitudinal circulating tumor DNA-based model associated with survival in metastatic non-small-cell lung cancer
One of the great challenges in therapeutic oncology is determining who might achieve
survival benefits from a particular therapy. Studies on longitudinal circulating tumor DNA …
survival benefits from a particular therapy. Studies on longitudinal circulating tumor DNA …
Support to early clinical decisions in drug development and personalised medicine with checkpoint inhibitors using dynamic biomarker-overall survival models
Longitudinal models of biomarkers such as tumour size dynamics capture treatment efficacy
and predict treatment outcome (overall survival) of a variety of anticancer therapies …
and predict treatment outcome (overall survival) of a variety of anticancer therapies …
Circulating tumour cells and PD-L1-positive small extracellular vesicles: the liquid biopsy combination for prognostic information in patients with metastatic non-small …
Z Eslami-S, LE Cortés-Hernández, L Sinoquet… - British Journal of …, 2024 - nature.com
Abstract Background Circulating tumour cells (CTCs), circulating tumour DNA (ctDNA), and
extracellular vesicles (EVs) are minimally invasive liquid biopsy biomarkers. This study …
extracellular vesicles (EVs) are minimally invasive liquid biopsy biomarkers. This study …
Early on-treatment changes in circulating tumor DNA fraction and response to enzalutamide or abiraterone in metastatic castration-resistant prostate cancer
Purpose: Androgen receptor pathway inhibitors (ARPI) are standard of care for treatment-
naïve metastatic castration-resistant prostate cancer (mCRPC), but rapid resistance is …
naïve metastatic castration-resistant prostate cancer (mCRPC), but rapid resistance is …
Explainable deep learning for tumor dynamic modeling and overall survival prediction using Neural-ODE
While tumor dynamic modeling has been widely applied to support the development of
oncology drugs, there remains a need to increase predictivity, enable personalized therapy …
oncology drugs, there remains a need to increase predictivity, enable personalized therapy …
Clinical and Molecular Features of Long-term Response to Immune Checkpoint Inhibitors in Patients with Advanced Non–Small Cell Lung Cancer
Purpose: We sought to identify features of patients with advanced non–small cell lung
cancer (NSCLC) who achieve long-term response (LTR) to immune checkpoint inhibitors …
cancer (NSCLC) who achieve long-term response (LTR) to immune checkpoint inhibitors …
Circulating Tumor DNA Kinetics Predict Progression-Free and Overall Survival in EGFR TKI–Treated Patients with EGFR-Mutant NSCLC (SWOG S1403)
PC Mack, J Miao, MW Redman, J Moon… - Clinical Cancer …, 2022 - AACR
Purpose: Dynamic changes in circulating tumor DNA (ctDNA) are under investigation as an
early indicator of treatment outcome. Experimental Design: Serial plasma ctDNA (baseline, 8 …
early indicator of treatment outcome. Experimental Design: Serial plasma ctDNA (baseline, 8 …
Liquid biopsy in lung cancer: biomarkers for the management of recurrence and metastasis
Liquid biopsies have emerged as a promising tool for the detection of metastases as well as
local and regional recurrence in lung cancer. Liquid biopsy tests involve analyzing a …
local and regional recurrence in lung cancer. Liquid biopsy tests involve analyzing a …