Intermittent fasting in the prevention and treatment of cancer

KK Clifton, CX Ma, L Fontana… - CA: a cancer journal for …, 2021 - Wiley Online Library
Chronic caloric restriction (CR) has powerful anticarcinogenic actions in both preclinical and
clinical studies but may be difficult to sustain. As an alternative to CR, there has been …

[HTML][HTML] Calorie restriction in humans: an update

J Most, V Tosti, LM Redman, L Fontana - Ageing research reviews, 2017 - Elsevier
Calorie restriction (CR), a nutritional intervention of reduced energy intake but with adequate
nutrition, has been shown to extend healthspan and lifespan in rodent and primate models …

Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in …

T Moro, G Tinsley, A Bianco, G Marcolin… - Journal of translational …, 2016 - Springer
Background Intermittent fasting (IF) is an increasingly popular dietary approach used for
weight loss and overall health. While there is an increasing body of evidence demonstrating …

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction

KA Escobar, NH Cole, CM Mermier… - Aging cell, 2019 - Wiley Online Library
Accumulation of dysfunctional and damaged cellular proteins and organelles occurs during
aging, resulting in a disruption of cellular homeostasis and progressive degeneration and …

Effects of two months of very low carbohydrate ketogenic diet on body composition, muscle strength, muscle area, and blood parameters in competitive natural body …

A Paoli, L Cenci, PL Pompei, N Sahin, A Bianco, M Neri… - Nutrients, 2021 - mdpi.com
Background: Ketogenic diet (KD) is a nutritional approach that restricts daily carbohydrates,
replacing most of the reduced energy with fat, while maintaining an adequate quantity of …

Hormonal and metabolic changes of aging and the influence of lifestyle modifications

MW Pataky, WF Young, KS Nair - Mayo Clinic Proceedings, 2021 - Elsevier
Increased life expectancy combined with the aging baby boomer generation has resulted in
an unprecedented global expansion of the elderly population. The growing population of …

Guidelines on the use of sex and gender in cardiovascular research

CW Usselman, ML Lindsey… - American Journal …, 2024 - journals.physiology.org
In cardiovascular research, sex and gender have not typically been considered in research
design and reporting until recently. This has resulted in clinical research findings from which …

Calorie restriction in humans inhibits the PI 3 K/AKT pathway and induces a younger transcription profile

EM Mercken, SD Crosby, DW Lamming, L JeBailey… - Aging cell, 2013 - Wiley Online Library
Caloric restriction (CR) and down‐regulation of the insulin/IGF pathway are the most robust
interventions known to increase longevity in lower organisms. However, little is known about …

[HTML][HTML] Calorie restriction and prevention of age-associated chronic disease

D Omodei, L Fontana - FEBS letters, 2011 - Elsevier
Life expectancy in the world has increased dramatically during the last century; the number
of older adults is expected to rise while the number of youths will decline in the near future …

Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study

JK Das, N Banskota, J Candia, ME Griswold… - Aging cell, 2023 - Wiley Online Library
The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied by
postponement of disease, preservation of function, and increased stress resistance. Whether …