Hebb postulated that, to store information in the brain, assemblies of excitatory neurons
coding for a percept are bound together via associative long-term synaptic plasticity. In this …

While the dopamine hypothesis has dominated schizophrenia research for several decades,
more recent studies have highlighted the role of fast synaptic transmitters and their receptors …

Subjective tinnitus is the conscious perception of sound in the absence of any acoustic
source. The literature suggests various tinnitus mechanisms, most of which invoke changes …

Fast-spiking (FS) interneurons are important elements of neocortical circuitry that constitute
the primary source of synaptic inhibition in adult cortex and impart temporal organization on …

We describe the role of Sox6 in cortical interneuron development, from a cellular to a
behavioral level. We identify Sox6 as a protein expressed continuously within MGE-derived …

The mechanistic underpinnings of autism remain a subject of debate and controversy. Why
do individuals with autism share an overlapping set of atypical behaviors and symptoms …

Transcription of Bdnf is controlled by multiple promoters, which drive expression of multiple
transcripts encoding for the same protein. Promoter IV contributes significantly to activity …

Cortical fast-spiking (FS) neurons generate high-frequency action potentials (APs) without
apparent frequency accommodation, thus providing fast and precise inhibition. However, the …

Brain plasticity refers to the ability of synaptic connections to adapt their function and
structure in response to experience, including environmental changes, sensory deprivation …

Abstract Individuals with Fragile X Syndrome (FXS) and autism spectrum disorder (ASD)
exhibit cognitive impairments, social deficits, increased anxiety, and sensory …