Nucleic-acid catalysts (ribozymes, DNA-and XNAzymes) cleave target (m) RNAs with high
specificity but have shown limited efficacy in clinical applications. Here we report on the in …

Simple Summary Recent studies highlight the complexity of long non-coding RNA (lncRNA)
genetic loci in the pathogenesis of complex diseases, including carcinogenesis and cancer …

Recent advances in RNA sequencing technologies helped uncover what was once
uncharted territory in the human genome—the complex and versatile world of long …

For the emergence of life, the abiotic synthesis of RNA from its monomers is a central step.
We found that in alkaline, drying conditions in bulk and at heated air‐water interfaces, 2 …

Like other functional RNAs, ribozymes encode a conserved catalytic center supported by
peripheral domains that vary among ribozyme sub-families. To understand how core …

Despite the big data era, observational data continue to be a limiting factor in the
environmental sciences. To collect the most informative field data, studies on the value of …

Functional nucleic acids can be evolved in vitro using cycles of selection and amplification,
starting from diverse-sequence libraries, which are typically restricted to natural or partially …

As discovery of cellular diversity in the brain accelerates, so does the need for tools that
target cells based on multiple features. Here we developed Conditional Viral Expression by …

Trillions of microorganisms, collectively known as the microbiome, inhabit our bodies with
the gut microbiome being of particular interest in biomedical research. Bacteriophages, the …

Self-cleaving ribozymes are RNA molecules that catalyze the cleavage of their own
phosphodiester backbones. These ribozymes are found in all domains of life and are also a …