Abstract Lipocalin-2 (LCN-2) is a novel, 198 amino acid adipocytokine also referred to as
neutrophil gelatinase-associated lipocalin (NGAL). LCN-2 is a circulatory protein …

Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and
contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular …

Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes.
The exact mechanism by which adipose tissue induces insulin resistance is still unclear. It …

Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions,
including type 2 diabetes, cardiovascular diseases, nonalcoholic fatty liver disease and …

Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory
cytokines, myokines, and osteokines, contribute substantially to the development of …

Osteoblasts are specialized mesenchymal cells that synthesize bone matrix and coordinate
the mineralization of the skeleton. These cells work in harmony with osteoclasts, which …

There has been an upsurge of interest in the adipocyte coincident with the onset of the
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

The NAD+-dependent deacetylase SIRT1 controls key metabolic functions by deacetylating
target proteins and strategies that promote SIRT1 function such as SIRT1 overexpression or …