Experimental chemotherapy-induced mucositis: a scoping review guiding the design of suitable preclinical models

J Huang, AYM Hwang, Y Jia, B Kim, M Iskandar… - International Journal of …, 2022 - mdpi.com
Mucositis is a common and most debilitating complication associated with the cytotoxicity of
chemotherapy. The condition affects the entire alimentary canal from the mouth to the anus …

Gut microbiota: A key role for human milk oligosaccharides in regulating host health early in life

Q Chen, X Ma, Z Guo, P Zhang, B Li… - … Reviews in Food …, 2024 - Wiley Online Library
Human milk oligosaccharides (HMOs) are an evolutionarily significant advantage bestowed
by mothers for facilitating the development of the infant's gut microbiota. They can avoid …

Current advances in structure–function relationships and dose-dependent effects of human milk oligosaccharides

J Wang, MS Chen, RS Wang, JQ Hu, S Liu… - Journal of Agricultural …, 2022 - ACS Publications
HMOs (human milk oligosaccharides) are the third most important nutrient in breast milk. As
complex glycans, HMOs play an important role in regulating neonatal intestinal immunity …

Gastrointestinal Self-Adaptive and Nutrient Self-Sufficient Akkermansia muciniphila–Gelatin Porous Microgels for Synergistic Therapy of Ulcerative Colitis

Y Zhang, Y Wang, X Zhang, P Wang, F Shi, Z Zhang… - ACS …, 2024 - ACS Publications
To realize effective and long-term synergistic therapy of ulcerative colitis (UC) with
probiotics, we developed gastrointestinal self-adaptive and nutrient self-sufficient …

Alginate oligosaccharide improves 5-fluorouracil-induced intestinal mucositis by enhancing intestinal barrier and modulating intestinal levels of butyrate and …

Y Teng, J Li, J Guo, C Yan, A Wang, X Xia - International Journal of …, 2024 - Elsevier
Chemotherapy-induced mucositis (CIM) is the typical side effect of chemotherapy. This study
investigates the potential of alginate oligosaccharide (AOS) in ameliorating CIM induced by …

Gastrointestinal inflammation plays a critical role in chemotherapy-induced nausea and vomiting

W Chen, Y Zhao, Y Dai, K Nie - European Journal of Pharmacology, 2022 - Elsevier
Chemotherapy-induced nausea and vomiting (CINV) is a common side effect of patients with
cancer receiving chemotherapeutic drugs. However, the pathological mechanism of CINV is …

Breastfeeding sick children in hospital: exploring the experiences of mothers in UK paediatric wards

L Hookway, A Brown, A Grant - Maternal & Child Nutrition, 2023 - Wiley Online Library
There is a paucity of literature exploring the challenges of breastfeeding sick children in
hospital. Previous research has focused on single conditions and hospitals which limits …

Specific human milk oligosaccharides differentially promote th1 and regulatory responses in a cpG-activated epithelial/immune cell coculture

M Zuurveld, V Ayechu-Muruzabal, G Folkerts… - Biomolecules, 2023 - mdpi.com
Proper early life immune development creates a basis for a healthy and resilient immune
system, which balances immune tolerance and activation. Deviations in neonatal immune …

Physiological and cognitive changes after treatments of cyclophosphamide, methotrexate, and fluorouracil: implications of the gut microbiome and depressive-like …

C Corley, T McElroy, B Sridharan, M Trujillo… - Frontiers in …, 2023 - frontiersin.org
Introduction Chemotherapy-induced cognitive impairment colloquially referred to as
chemobrain is a poorly understood phenomenon affecting a highly variable proportion of …

Akkermansia muciniphila and its outer membrane protein Amuc_1100 prophylactically attenuate 5-fluorouracil-induced intestinal mucositis

S Chen, K Qian, G Zhang, M Zhang - Biochemical and biophysical research …, 2022 - Elsevier
Fluorouracil (5-FU) is a chemotherapy drug used to treat tumors. Previous studies have
shown that Akkermansia muciniphila (A. muciniphila) and its outer membrane protein …