Contemporary analyses of cell metabolism have called out three metabolites: ATP, NADH,
and acetyl-CoA, as sentinel molecules whose accumulation represent much of the purpose …

Arabidopsis genes encoding enzymes for each of the eight steps in l-arginine (Arg)
synthesis were identified, based upon sequence homologies with orthologs from other …

Metabolism is a fundamental cellular process that is coordinated with cell cycle progression.
Despite this association, a mechanistic understanding of cell cycle phase-dependent …

Staphylococcus aureus is a zoonotic opportunistic pathogen that represents a significant
threat to public health. Previous studies have shown that tannic acid (TA) has an inhibitory …

We review literature on the metabolism of ribo-and deoxyribonucleotides, nucleosides, and
nucleobases in Escherichia coli and Salmonella, including biosynthesis, degradation …

In all organisms, carbamoylphosphate (CP) is a precursor common to the synthesis of
arginine and pyrimidines. In Escherichia coli and most other Gram-negative bacteria, CP is …

CAD is a 1.5 MDa particle formed by hexameric association of a 250 kDa protein that carries
the enzymatic activities for the first three steps in the de novo biosynthesis of pyrimidine …

A fascinating group of enzymes has been shown to possess multiple active sites connected
by intramolecular tunnels for the passage of reactive intermediates from the site of …

The electrophilic lipid 15-deoxy-Δ12, 14-prostaglandin J2 (15d-PGJ2) is known to allow
adaptation to oxidative stress in cells at low concentrations and apoptosis at high levels. The …

Four decades ago, several scientists suggested that the impossibility of any evolutionary
process sampling anything but a miniscule fraction of the possible protein sequences posed …