Failure to complete DNA replication is one of the major sources of genome instability
leading to aneuploidy, chromosome breakage, and chromosome rearrangements that are …

In the cell nucleus, DNA damage signaling and repair machineries operate on a chromatin
substrate, the integrity of which is critical for cell function and viability. Here, we review …

Homologous recombination (HR) is a major pathway to repair DNA double-strand breaks
(DSB). HR uses an undamaged homologous DNA sequence as a template for copying the …

The substrate for the repair of DNA damage in living cells is not DNA but chromatin.
Chromatin bears a range of modifications, which in turn bind ligands that compact or open …

DNA double-strand breaks (DSBs) are harmful DNA lesions, which elicit catastrophic
consequences for genome stability if not properly repaired. DSBs can be repaired by either …

Upon DNA damage, numerous proteins are targeted for ubiquitin-dependent proteasomal
degradation, which is an integral part of the DNA repair program. Although details of the …

Over thirty years have passed since the first description of ubiquitin-positive structures in the
brain of patients suffering from Alzheimer's disease. Meanwhile, the intracellular …

Two related post‐translational modifications, the covalent linkage of Ubiquitin and the Small
Ubiquitin‐related MOdifier (SUMO) to lysine residues, play key roles in the regulation of both …

Eukaryotic organisms adapt to environmental fluctuations by altering their epigenomic
landscapes and transcriptional programs. Nucleosomal histones carry vital epigenetic …

Highlights•Nuclear actin filaments and myosins drive the directed motions of
heterochromatic repair sites.•Local and global changes in heterochromatin dynamics …