From discoveries in ageing research to therapeutics for healthy ageing
For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
The proteostasis network and its decline in ageing
Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …
Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis
KC Stein, F Morales-Polanco, J van der Lienden… - Nature, 2022 - nature.com
Ageing is accompanied by a decline in cellular proteostasis, which underlies many age-
related protein misfolding diseases,. Yet, how ageing impairs proteostasis remains unclear …
related protein misfolding diseases,. Yet, how ageing impairs proteostasis remains unclear …
The amyloid state and its association with protein misfolding diseases
TPJ Knowles, M Vendruscolo… - Nature reviews Molecular …, 2014 - nature.com
The phenomenon of protein aggregation and amyloid formation has become the subject of
rapidly increasing research activities across a wide range of scientific disciplines. Such …
rapidly increasing research activities across a wide range of scientific disciplines. Such …
The biology of proteostasis in aging and disease
J Labbadia, RI Morimoto - Annual review of biochemistry, 2015 - annualreviews.org
Loss of protein homeostasis (proteostasis) is a common feature of aging and disease that is
characterized by the appearance of nonnative protein aggregates in various tissues. Protein …
characterized by the appearance of nonnative protein aggregates in various tissues. Protein …
Widespread proteome remodeling and aggregation in aging C. elegans
Aging has been associated with a progressive decline of proteostasis, but how this process
affects proteome composition remains largely unexplored. Here, we profiled more than …
affects proteome composition remains largely unexplored. Here, we profiled more than …
The UPRER: sensor and coordinator of organismal homeostasis
Life is stressful. Organisms are repeatedly exposed to stressors that disrupt protein
homeostasis (proteostasis), resulting in protein misfolding and aggregation. To sense and …
homeostasis (proteostasis), resulting in protein misfolding and aggregation. To sense and …
Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster
The accumulation of dysfunctional mitochondria has been implicated in aging, but a deeper
understanding of mitochondrial dynamics and mitophagy during aging is missing. Here, we …
understanding of mitochondrial dynamics and mitophagy during aging is missing. Here, we …
Adaptive homeostasis and the free radical theory of ageing
LCD Pomatto, KJA Davies - Free Radical Biology and Medicine, 2018 - Elsevier
Abstract The Free Radical Theory of Ageing, was first proposed by Denham Harman in the
mid-1950's, based largely on work conducted by Rebeca Gerschman and Daniel Gilbert. At …
mid-1950's, based largely on work conducted by Rebeca Gerschman and Daniel Gilbert. At …
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation
E Kelmer Sacramento, JM Kirkpatrick… - Molecular systems …, 2020 - embopress.org
A progressive loss of protein homeostasis is characteristic of aging and a driver of
neurodegeneration. To investigate this process quantitatively, we characterized proteome …
neurodegeneration. To investigate this process quantitatively, we characterized proteome …