Growth hormone (GH) deficiency (GHD) in children is defined as impaired production of GH
by the pituitary gland that results in growth failure. This disease might be congenital or …

The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …

Since hypothalamic obesity (HyOb) was first described over 120 years ago by Joseph
Babinski and Alfred Fröhlich, advances in molecular genetic laboratory techniques have …

Background Septo-optic dysplasia (SOD) is a rare condition diagnosed in children with two
or more of the following: hypopituitarism, midline brain abnormalities, and optic nerve …

Unexplained or idiopathic pituitary stalk thickening or central diabetes insipidus not only
harbours rare occult malignancies in 40% of cases but can also reflect benign congenital …

Purpose Congenital hypopituitarism (CH) disorders are phenotypically variable. Variants in
multiple genes are associated with these disorders, with variable penetrance and …

Context The international GENHYPOPIT network collects phenotypical data and screens
genetic causes of non‐acquired hypopituitarism. Aims To describe main phenotype patterns …

Hypopituitarism in childhood is a rare, complex disorder that can present with highly variable
phenotypes, which may continue into adult life. Pituitary deficits can evolve over time, with …

Obesity is increasing worldwide, including in pediatrics. Adequate nutrition is required for
initiation of menses, and there is a clear secular trend toward earlier pubertal onset and …

Puberty is a biological process that represents the development of secondary sexual
characteristics and attainment of reproductive capacity, influenced by genetic, metabolic …