Activation of the unfolded protein response in response to endoplasmic reticulum stress
preserves cell viability and function under stressful conditions. Nevertheless, persistent …

Oligodendroglia play a critical role in CNS homeostasis by myelinating neuronal axons in
their mature stages. Dysfunction in this lineage occurs when early stage OPCs are not able …

Mammalian cells respond to insufficient oxygen through transcriptional regulators called
hypoxia-inducible factors (HIFs). Although transiently protective, prolonged HIF activity …

Circular RNAs (circRNAs) are evolutionarily conserved and tissue-specific types of non-
coding RNA and can serve as potential diagnostic biomarkers for disease. However, the …

Emerging evidence from experimental and clinical research suggests that stress-related
genes may play key roles in AD development. The fact that genome-wide association …

Background: Periventricular leukomalacia (PVL) is the major form of brain injury in
premature infants. Currently, there are no therapies to treat PVL. Several studies suggested …

Genome-wide association studies (GWAS) have allowed us to successfully identify
thousands of common genetic variants underlying a number of diseases, but it has been …

All mammalian cells sense and respond to insufficient oxygen, or hypoxia, through the
activity of hypoxia-inducible factors (HIFs), an evolutionarily conserved family of …

Activation of the unfolded protein response in response to endoplasmic reticulum stress
preserves cell viability and function under stressful conditions. Nevertheless, persistent …

Loss of premyelinating oligodendrocytes during early neurodevelopment is a problem of
great importance because the effects are long lasting. Approximately 60,000 infants are …