Plant genomes encode various small RNAs that function in distinct, yet overlapping, genetic
and epigenetic silencing pathways. However, the abundance and diversity of small-RNA …

Micro-RNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) that act as post-
transcriptional regulators of gene expression. Since their discovery in 1993, they have been …

Small RNA molecules regulate eukaryotic gene expression during development and in
response to stresses including viral infection. Specialized ribonucleases and RNA-binding …

Blastemal histology in chemotherapy-treated pediatric Wilms tumors (nephroblastoma) is
associated with adverse prognosis. To uncover the underlying tumor biology and find …

The RNA-induced silencing complex, comprising Argonaute and guide RNA, mediates RNA
interference. Here we report the 3.2 Å crystal structure of Kluyveromyces polysporus …

RNA silencing is a eukaryote‐specific phenomenon in which microRNAs and small
interfering RNAs degrade messenger RNAs containing a complementary sequence. To this …

The double-stranded RNA binding domain (dsRBD) is a small protein domain of 65–70
amino acids adopting an αβββα fold, whose central property is to bind to double-stranded …

Dicer is a multidomain enzyme that generates small RNAs for gene silencing in eukaryotes.
Current understanding of Dicer structure is restricted to simple forms of the enzyme, whereas …

MicroRNAs (miRNAs) originate from primary transcripts (pri-miRNAs) with characteristic
stem-loop structures, and their accurate processing is required for the production of …

The RNA interference pathway (RNAi) is executed by two core enzymes, Dicer and
Argonaute, for accomplishing a tailored transcriptional and post-transcriptional gene …