Abstract The Receptor for Activated C Kinase 1 (RACK1) is a member of the tryptophan-
aspartate repeat (WD-repeat) family of proteins and shares significant homology to the β …

Ras and Rho proteins are GTP-regulated molecular switches that control multiple signaling
pathways in eukaryotic cells. Ras was among the first identified oncogenes, and it appears …

Apico-basal polarity is typical of cells present in differentiated epithelium while front-rear
polarity develops in motile cells. In cancer development, the transition from epithelial to …

RACK1 is a highly conserved intracellular adaptor protein with significant homology to Gβ
and was originally identified as the anchoring protein for activated protein kinase C. In the …

Cell movement begins with a leading edge protrusion, which is stabilized by nascent
adhesions and retracted by mature adhesions. The ERK-MAPK (extracellular signal …

TDP-43 is a well known RNA binding protein involved in the pathogenesis of Amyotrophic
Lateral Sclerosis (ALS) and Frontotemporal Lobar Dementia (FTLD). In physiological …

Hyaluronan (HA) modulates key cancer cell functions through interaction with its CD44 and
receptor for hyaluronic acid-mediated motility (RHAMM) receptors. HA was recently found to …

The extracellular signal‐regulated kinase cascade is a central signaling pathway that is
stimulated by various extracellular stimuli. The signals of these stimuli are then transferred …

Coordinated translation initiation is coupled with cell cycle progression and cell growth,
whereas excessive ribosome biogenesis and translation initiation often lead to tumor …

The mitogen-activated protein kinase (MAPK) pathway is the canonical signaling pathway
for many receptor tyrosine kinases, such as the Epidermal Growth Factor Receptor …