Most human embryos are aneuploid. Aneuploidy frequently arises during the early mitotic
divisions of the embryo, but its origin remains elusive. Human zygotes that cluster their …

About 8 out of 10 human embryos obtained in vitro harbour chromosomal abnormalities of
either meiotic or mitotic origin. Abnormalities of mitotic origin lead to chromosomal …

The first mitosis of the mammalian embryo must partition the parental genomes contained in
two pronuclei. In rodent zygotes, sperm centrosomes are degraded, and instead, acentriolar …

Preimplantation development is well conserved across mammalian species, but major
differences in developmental kinetics, regulation of early lineage differentiation and …

Direct cleavage, a type of abnormal cleavage in which one zygote divides into three or more
blastomeres, has been reported in mammals. The incidence of direct cleavage increases in …

The first mitosis of the mammalian embryo must partition the parental genomes contained in
two pronuclei. In rodent zygotes, sperm centrosomes are degraded and, instead, acentriolar …

This dissertation is dedicated to developing an extended culture medium that will support
the growth of cattle embryos outside the uterine environment beyond the current seven-day …

During human pre-implantation development a totipotent zygote develops into a competent
blastocyst ready for implantation 7 days post fertilisation (dpf). The segregation into …