Therapeutic targeting of oncogenic tyrosine phosphatases
Protein tyrosine phosphatases (PTP) are exciting and novel targets for cancer drug
discovery that work in concert with protein tyrosine kinases (PTK) in controlling cellular …
discovery that work in concert with protein tyrosine kinases (PTK) in controlling cellular …
[HTML][HTML] Recent advances in the structural biology of Mg2+ channels and transporters
Abstract Magnesium ions (Mg 2+) are the most abundant divalent cations in living organisms
and are essential for various physiological processes, including ATP utilization and the …
and are essential for various physiological processes, including ATP utilization and the …
The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics
A Kollewe, V Chubanov, FT Tseung, L Correia… - Elife, 2021 - elifesciences.org
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously
expressed membrane protein consisting of ion channel and protein kinase domains. TRPM7 …
expressed membrane protein consisting of ion channel and protein kinase domains. TRPM7 …
Structural basis for the Mg2+ recognition and regulation of the CorC Mg2+ transporter
The CNNM/CorC family proteins are Mg2+ transporters that are widely distributed in all
domains of life. In bacteria, CorC has been implicated in the survival of pathogenic …
domains of life. In bacteria, CorC has been implicated in the survival of pathogenic …
Crystal structure of an archaeal CorB magnesium transporter
CNNM/CorB proteins are a broadly conserved family of integral membrane proteins with
close to 90,000 protein sequences known. They are associated with Mg2+ transport but it is …
close to 90,000 protein sequences known. They are associated with Mg2+ transport but it is …
Considerations for defining+ 80 Da mass shifts in mass spectrometry-based proteomics: phosphorylation and beyond
Post-translational modifications (PTMs) are ubiquitous and key to regulating protein function.
Understanding the dynamics of individual PTMs and their biological roles requires robust …
Understanding the dynamics of individual PTMs and their biological roles requires robust …
The oncogenic PRL protein causes acid addiction of cells by stimulating lysosomal exocytosis
Extracellular pH is usually maintained around 7.4 in multicellular organisms, and cells are
optimized to proliferate under this condition. Here, we find cells can adapt to a more acidic …
optimized to proliferate under this condition. Here, we find cells can adapt to a more acidic …
Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism
S Hardy, E Kostantin, SJ Wang… - Proceedings of the …, 2019 - National Acad Sciences
Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1,
PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the …
PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the …
Physiological and oncogenic roles of the PRL phosphatases
S Hardy, E Kostantin, T Hatzihristidis… - The FEBS …, 2018 - Wiley Online Library
The human Phosphatase of Regenerative Liver (PRL) family comprises three members
(PRL‐1,‐2,‐3; gene name PTP 4A1, PTP 4A2, PTP 4A3) that are highly expressed in a …
(PRL‐1,‐2,‐3; gene name PTP 4A1, PTP 4A2, PTP 4A3) that are highly expressed in a …
Mg2+-ATP sensing in CNNM, a putative magnesium transporter
The family of cystathionine-β-synthase (CBS)-pair domain divalent metal cation transport
mediators (CNNMs) is composed of four integral membrane proteins associated with Mg 2+ …
mediators (CNNMs) is composed of four integral membrane proteins associated with Mg 2+ …