Aldehyde oxidase (AO) catalyzes oxidations of azaheterocycles and aldehydes, amide
hydrolysis, and diverse reductions. AO substrates are rare among marketed drugs, and …

MET has been considered as a promising drug target for the treatment of MET-dependent
diseases, particularly non-small cell lung cancer (NSCLC). Small molecule MET inhibitors …

The quinoline molecule is a chemical motif showing a highly promising pharmacological
potential. Its numerous derivatives introduced into medicine revolutionized in the treatment …

Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts,
making it an attractive target for both imaging and therapy of malignancy. This study …

This is an overview of the metabolic reactions of drugs, natural products, physiological
compounds, and other (general) chemicals catalyzed by flavin monooxygenase (FMO) …

Artificial intelligence (AI) has undergone rapid development in recent years and has been
successfully applied to real-world problems such as drug design. In this chapter, we review …

The quinoline ring system has long been known as a versatile nucleus in the design and
synthesis of biologically active compounds. Currently, more than one hundred quinoline …

Breast cancer is the most common malignancy among women, posing a formidable health
challenge worldwide. In this complex landscape, the c-MET (cellular-mesenchymal …

Aldehyde oxidase (AO) has garnered curiosity as a non-CYP metabolizing enzyme in drug
development due to unexpected consequences such as toxic metabolite generation and …

The propensity for aldehyde oxidase (AO) substrates to be implicated in drug-drug
interactions (DDIs) is not well understood due to the dearth of potent inhibitors that elicit in …