The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non …

According to the 'multiple‐hit'hypothesis, several factors can act simultaneously in
nonalcoholic fatty liver disease (NAFLD) progression. Increased nitro‐oxidative (nitroso …

Nonalcoholic fatty liver diseases (NAFLD) represent a set of liver disorders progressing from
steatosis to steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma, which induce …

The liver is a major organ that coordinates the metabolic flexibility of the whole body, which
is characterized by the ability to adapt dynamically in response to fluctuations in energy …

Mitochondria are critical cellular organelles for energy generation and are now also
recognized as playing important roles in cellular signaling. Their central role in energy …

Reactive oxygen species, when released under controlled conditions and limited amounts,
contribute to cellular proliferation, senescence, and survival by acting as signaling …

Mitochondrial dysfunction is increasingly implicated in the etiology of drug-induced toxicities.
Members of diverse drug classes undermine mitochondrial function, and among the most …

Non-alcoholic fatty liver disease encompasses a spectrum of liver diseases, including
simple steatosis, steatohepatitis, liver fibrosis and cirrhosis and hepatocellular carcinoma …

Reactive oxygen species (ROS) can surely be considered as multifunctional biofactors
within the cell. They are known to participate in regular cell functions, for example, as signal …

Valproic acid (VPA) is an anti-seizure drug that causes idiosyncratic liver injury. 2-propyl-4-
pentenoic acid (Δ 4 VPA), a metabolite of VPA, has been implicated in VPA-induced …