SP-A and SP-D: dual functioning immune molecules with antiviral and immunomodulatory properties

A Watson, J Madsen, HW Clark - Frontiers in Immunology, 2021 - frontiersin.org
Surfactant proteins A (SP-A) and D (SP-D) are soluble innate immune molecules which
maintain lung homeostasis through their dual roles as anti-infectious and …

Surfactant protein D in respiratory and non-respiratory diseases

GL Sorensen - Frontiers in medicine, 2018 - frontiersin.org
Surfactant protein D (SP-D) is a multimeric collectin that is involved in innate immune
defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts …

Lipid–protein and protein–protein interactions in the pulmonary surfactant system and their role in lung homeostasis

O Cañadas, B Olmeda, A Alonso… - International journal of …, 2020 - mdpi.com
Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and
secreted into the airspaces, where it coats and protects the large respiratory air–liquid …

Influenza Virus Primes Mice for Pneumonia From Staphylococcus aureus

AR Iverson, KL Boyd, JL McAuley… - Journal of Infectious …, 2011 - academic.oup.com
Superinfections from Staphylococcus aureus following influenza are an increasing concern.
We assessed several laboratory and clinical strains in a mouse coinfection model with …

Gp-340/DMBT1 in mucosal innate immunity

J Madsen, J Mollenhauer, U Holmskov - Innate immunity, 2010 - journals.sagepub.com
Deleted in Malignant Brain Tumour 1 (DMBT1) is a gene that encodes alternatively spliced
proteins involved in mucosal innate immunity. It also encodes a glycoprotein with a …

New treatments for influenza

S Barik - BMC medicine, 2012 - Springer
Influenza has a long history of causing morbidity and mortality in the human population
through routine seasonal spread and global pandemics. The high mutation rate of the RNA …

Antiviral activities in human saliva

D Malamud, WR Abrams, CA Barber… - Advances in dental …, 2011 - journals.sagepub.com
In this review, the authors survey the large number of antibacterial and antiviral proteins
present in human saliva. Of interest, most of these antibacterial proteins display antiviral …

Human neutrophil defensins increase neutrophil uptake of influenza A virus and bacteria and modify virus-induced respiratory burst responses

T Tecle, MR White, D Gantz, EC Crouch… - The Journal of …, 2007 - journals.aai.org
Human neutrophil peptides (HNPs) are released from granules of neutrophils in response to
various activating stimuli and they participate in the killing of bacteria and the stimulation of …

Collectins: innate immune pattern recognition molecules

V Murugaiah, AG Tsolaki, U Kishore - Lectin in host defense against …, 2020 - Springer
Collectins are collagen-containing C-type (calcium-dependent) lectins which are important
pathogen pattern recognising innate immune molecules. Their primary structure is …

Salivary agglutinin/glycoprotein-340/DMBT1: a single molecule with variable composition and with different functions in infection, inflammation and cancer

AJM Ligtenberg, ECI Veerman, AV Nieuw Amerongen… - 2007 - degruyter.com
Salivary agglutinin (SAG), lung glycoprotein-340 (gp-340) and Deleted in Malignant Brain
Tumours 1 (DMBT1) are three names for identical proteins encoded by the dmbt1 gene …