Primary Amoebic Meningoencephalitis by Naegleria fowleri: Pathogenesis and Treatments

A Güémez, E García - Biomolecules, 2021 - mdpi.com
Naegleria fowleri is a free-living amoeba (FLA) that is commonly known as the “brain-eating
amoeba.” This parasite can invade the central nervous system (CNS), causing an acute and …

Drug discovery for primary amebic meningoencephalitis: from screen to identification of leads

A Debnath - Expert review of anti-infective therapy, 2021 - Taylor & Francis
Introduction: Naegleria fowleri is responsible for primary amebic meningoencephalitis (PAM)
which has a fatality rate of> 97%. Because of the rarity of the disease, pharmaceutical …

Structural informatics approach for designing an epitope-based vaccine against the brain-eating Naegleria fowleri

A Sarfraz, TU Wara, Sheheryar, K Chen… - Frontiers in …, 2023 - frontiersin.org
Primary Amoebic Meningoencephalitis (PAM), a severe lethal brain disease, is caused by a
parasite, Naegleria fowleri, also known as the “brain-eating amoeba”. The chances of a …

Natural Terpenes Inhibit the Cytopathogenicity of Naegleria fowleri Causing Primary Amoebic Meningoencephalitis in the Human Cell Line Model

K Rajendran, U Ahmed, AC Meunier… - ACS Chemical …, 2023 - ACS Publications
Naegleria fowleri is one of the free-living amoebae and is a causative agent of a lethal and
rare central nervous system infection called primary amoebic meningoencephalitis. Despite …

A Broad Spectrum Antiparasitic Activity of Organotin (IV) Derivatives and Its Untargeted Proteomic Profiling Using Leishmania donovani

O Hayat, N Ullah, M Sirajuddin, MA Giardini… - Pathogens, 2022 - mdpi.com
Metals have been used in medicine since ancient times for the treatment of different ailments
with various elements such as iron, gold and arsenic. Metal complexes have also been …

Cyanomethyl Vinyl Ethers Against Naegleria fowleri

J Chao-Pellicer, I Arberas-Jiménez… - ACS Chemical …, 2023 - ACS Publications
Naegleria fowleri is a pathogenic amoeba that causes a fulminant and rapidly progressive
disease affecting the central nervous system called primary amoebic meningoencephalitis …

A Fluorometric Assay for the In Vitro Evaluation of Activity against Naegleria fowleri Cysts

I Arberas-Jiménez, A Rizo-Liendo, I Sifaoui… - Microbiology …, 2022 - Am Soc Microbiol
Primary amoebic meningoencephalitis (PAM) is a lethal and rapid infection that affects the
central nervous system and is caused by the free-living amoeba Naegleria fowleri. The life …

[HTML][HTML] Cyclolauranes as plausible chemical scaffold against Naegleria fowleri

I Arberas-Jimenez, S García-Davis… - Biomedicine & …, 2022 - Elsevier
Primary amoebic meningoencephalitis (PAM) is a central nervous system (CNS) disease
caused by Naegleria fowleri that mainly affects children and young adults with fatal …

HMG-CoA Reductase Inhibitors as Drug Leads against Naegleria fowleri

HJ Hahn, R Abagyan, LM Podust, S Roy… - ACS chemical …, 2020 - ACS Publications
Primary amebic meningoencephalitis (PAM), caused by the free-living ameba Naegleria
fowleri, has a fatality rate of over 97%. Treatment of PAM relies on amphotericin B in …

[HTML][HTML] Fluvastatin and atorvastatin induce programmed cell death in the brain eating amoeba Naegleria fowleri

A Rizo-Liendo, I Sifaoui, I Arberas-Jiménez… - Biomedicine & …, 2020 - Elsevier
Naegleria fowleri is the causative agent of a type of encephalitis called Primary Amoebic
Encephalitis (PAM). Almost 98% of PAM cases reported worldwide are fatal and affect …