microRNAs in action: biogenesis, function and regulation

R Shang, S Lee, G Senavirathne, EC Lai - Nature Reviews Genetics, 2023 - nature.com
Ever since microRNAs (miRNAs) were first recognized as an extensive gene family> 20
years ago, a broad community of researchers was drawn to investigate the universe of small …

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

R Rupaimoole, FJ Slack - Nature reviews Drug discovery, 2017 - nature.com
In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …

A tetrahedral framework DNA‐based bioswitchable miRNA inhibitor delivery system: application to skin anti‐aging

S Li, Y Liu, T Zhang, S Lin, S Shi, J He, Y Xie… - Advanced …, 2022 - Wiley Online Library
MicroRNA (miR)‐based therapy shows strong potential; however, structural limitations pose
a challenge in fully exploiting its biomedical functionality. Tetrahedral framework DNA (tFNA) …

RNA-binding proteins in cancer: old players and new actors

B Pereira, M Billaud, R Almeida - Trends in cancer, 2017 - cell.com
RNA-binding proteins (RBPs) are key players in post-transcriptional events. The
combination of versatility of their RNA-binding domains with structural flexibility enables …

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

F Zanconato, M Forcato, G Battilana, L Azzolin… - Nature cell …, 2015 - nature.com
YAP/TAZ are nuclear effectors of the Hippo pathway regulating organ growth and
tumorigenesis. Yet, their function as transcriptional regulators remains underinvestigated. By …

[HTML][HTML] Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis

SA Melo, H Sugimoto, JT O'Connell, N Kato… - Cancer cell, 2014 - cell.com
Exosomes are secreted by all cell types and contain proteins and nucleic acids. Here, we
report that breast cancer associated exosomes contain microRNAs (miRNAs) associated …

miRNA deregulation in cancer cells and the tumor microenvironment

R Rupaimoole, GA Calin, G Lopez-Berestein, AK Sood - Cancer discovery, 2016 - AACR
Abstract miRNAs are a key component of the noncoding RNA family. The underlying
mechanisms involved in the interplay between the tumor microenvironment and cancer cells …

Pathophysiological implications of hypoxia in human diseases

PS Chen, WT Chiu, PL Hsu, SC Lin, IC Peng… - Journal of biomedical …, 2020 - Springer
Oxygen is essentially required by most eukaryotic organisms as a scavenger to remove
harmful electron and hydrogen ions or as a critical substrate to ensure the proper execution …

Network regulation of microRNA biogenesis and target interaction

S Komatsu, H Kitai, HI Suzuki - Cells, 2023 - mdpi.com
MicroRNAs (miRNAs) are versatile, post-transcriptional regulators of gene expression.
Canonical miRNAs are generated through the two-step DROSHA-and DICER-mediated …

A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis

B Liu, L Sun, Q Liu, C Gong, Y Yao, X Lv, L Lin, H Yao… - Cancer cell, 2015 - cell.com
NF-κB is a critical link between inflammation and cancer, but whether long non-coding RNAs
(lncRNAs) regulate its activation remains unknown. Here, we identify an NF-KappaB …