Aging is associated with complex biological changes that can be accelerated, slowed, or
even temporarily reversed by biological and non-biological factors. This article focuses on …

In seeking to understand mental health and disease, it is fundamental to identify the
biological substrates that draw together the experiences and physiological processes that …

Background Studies often evaluate mental health and well-being in association with
individual health behaviours although evaluating multiple health behaviours that co-occur in …

Major depressive disorder (MDD) has been linked to mitochondrial defects, which could
manifest in mitochondrial DNA (mtDNA) polymorphisms or mutations. Additionally, copy …

Mitochondria carry their own circular genome and disruption of the mitochondrial genome is
associated with various aging-related diseases. Unlike the nuclear genome, mitochondrial …

Major depressive disorder (MDD) is highly prevalent in adolescents and is a major risk factor
for suicidality. Recent evidence shows that accelerated cellular senescence/aging is …

Suicides have increased to over 48,000 deaths yearly in the United States. Major depressive
disorder (MDD) is the most common diagnosis among suicides, and identifying those at the …

Preclinical data suggest that chronic stress may cause cellular damage and mitochondrial
dysfunction, potentially leading to the release of mitochondrial DNA (mtDNA) into the …

Major depressive disorder (MDD) and bipolar disorder (BD), are globally prevalent,
contributing to significant disease burden and adverse health outcomes. These mood …

Objective Childhood maltreatment is a major risk factor for the development of behavioral
problems and poor physical and mental health. Accelerated cellular aging, through reduced …