Traditional herbal medicine: Therapeutic potential in rheumatoid arthritis

Y Wang, S Chen, K Du, C Liang, S Wang… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Rheumatoid arthritis (RA) is a chronic inflammatory
autoimmune disease influenced by diverse endogenous and exogenous factors. It is …

Influence of resveratrol on the immune response

L Malaguarnera - Nutrients, 2019 - mdpi.com
Resveratrol is the most well-known polyphenolic stilbenoid, present in grapes, mulberries,
peanuts, rhubarb, and in several other plants. Resveratrol can play a beneficial role in the …

SIRT1: a potential therapeutic target in autoimmune diseases

P Shen, X Deng, Z Chen, X Ba, K Qin, Y Huang… - Frontiers in …, 2021 - frontiersin.org
The morbidity and mortality of autoimmune diseases (Ads) have been increasing worldwide,
and the identification of novel therapeutic strategies for prevention and treatment is urgently …

Resveratrol and immune cells: a link to improve human health

A Alesci, N Nicosia, A Fumia, F Giorgianni, A Santini… - Molecules, 2022 - mdpi.com
The use of polyphenols as adjuvants in lowering risk factors for various debilitating diseases
has been investigated in recent years due to their possible antioxidant action. Polyphenols …

The effect of resveratrol on the cardiovascular system from molecular mechanisms to clinical results

R Gal, L Deres, K Toth, R Halmosi, T Habon - International journal of …, 2021 - mdpi.com
Cardiovascular diseases are the leading causes of death worldwide. The cardioprotective
effects of natural polyphenols such as resveratrol (3, 5, 4-trihydroxystilbene) have been …

Resveratrol suppresses microglial activation and promotes functional recovery of traumatic spinal cord via improving intestinal microbiota

N He, G Shen, X Jin, H Li, J Wang, L Xu, J Chen… - Pharmacological …, 2022 - Elsevier
Spinal cord injury (SCI) can change the intestinal microbiota pattern and corresponding
metabolites, which in turn affect the prognosis of SCI. Among many metabolites, short-chain …

Resveratrol-induced signal transduction in wound healing

AL Pignet, M Schellnegger, A Hecker… - International Journal of …, 2021 - mdpi.com
Resveratrol is a well-known polyphenol that harbors various health benefits. Besides its well-
known anti-oxidative potential, resveratrol exerts anti-inflammatory, pro-angiogenic, and cell …

Targeting Sirtuin1 to treat aging-related tissue fibrosis: From prevention to therapy

X Han, C Ding, XN Sang, MY Peng, Q Yang… - Pharmacology & …, 2022 - Elsevier
Fibrosis, which is characterized by excessive extracellular matrix (ECM) deposition, is a
wound-healing response to organ injury and may promote cancer and failure in various …

Epigenetic regulatory mechanisms induced by resveratrol

GFS Fernandes, GDB Silva, AR Pavan, DE Chiba… - Nutrients, 2017 - mdpi.com
Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its
potential therapeutic use in the treatment of many diseases, including cancer, diabetes …

METTL3 promotes activation and inflammation of FLSs through the NF-κB signaling pathway in rheumatoid arthritis

W Shi, Y Zheng, S Luo, X Li, Y Zhang, X Meng… - Frontiers in …, 2021 - frontiersin.org
Rheumatoid arthritis (RA), a common autoimmune disease, is extremely damaging to
human health. Fibroblast-like synoviocytes (FLSs) have a vital role in the occurrence and …