The association between inflammation, infection, and venous thrombosis has long been
recognized; yet, only in the last decades have we begun to understand the mechanisms …

In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively
participate in both innate and adaptive immune responses. We previously reported that, in …

To understand the placement of a certain protein in a physiological system and the
pathogenesis of related disorders, it is not only of interest to determine its function but also …

Endothelial cells are a constitutive part of the heart and vasculature and form a crucial link
between the cardiovascular system and the immune system. Besides their commonly …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Several important physiological processes, from permeability to inflammation to hemostasis,
take place at the vessel wall and are regulated by endothelial cells (ECs). Thus, proteins that …

Increasing evidence indicates that inflammation promotes thrombosis via a VWF (von
Willebrand factor)-mediated mechanism. VWF plays an essential role in maintaining the …

Acute and chronic inflammation is associated with changes in microvascular form and
function. At rest, endothelial cells maintain a nonthrombogenic, nonreactive surface at the …

Acute pancreatitis (AP) is an inflammatory disease with varied severity, ranging from mild
local inflammation to severe systemic involvement resulting in substantial mortality. Early …

Osteoarthritis (OA) is a whole-joint disease characterized by subchondral bone perfusion
abnormalities and neovascular invasion into the synovium and articular cartilage. In addition …