Abstract Poly (amidoamine)(PAMAM) dendrimers are well-defined, highly branched
macromolecules with numerous active amine groups on the surface. Because of their …

Short interfering RNAs (siRNAs), as small non-coding RNA fragments, are one of the widely
studied RNAi inducers for gene modulations. The reasonably designed siRNA probes …

Theranostic nanotherapeutic strategy has been widely emphasized now a day to develop
next-generation nanomedicine. Dendrimer-entrapped gold nanoparticles (DE-Au-NP) have …

Nanocarriers play an important role in drug delivery for disease treatment. However,
nanocarriers face a series of physiological barriers after administration such as blood …

Abstract Treatment of malignant glioma is a challenge facing cancer therapy. In addition to
surgery, and chemotherapy, radiotherapy (RT) is one of the most effective modalities of …

Despite advances in cancer therapy, effective local treatment remains a formidable
challenge due to the limit of efficient drug delivery method and the toxicity of …

RNA interference (RNAi) holds one of the promising tools for Alzheimer's disease (AD)
treatment by directly arresting the causative genes. For successful RNAi therapeutics for AD …

Cancer is a broad term for a class of prevalent diseases as one in three people develop
cancer during their lifetime. Although, there are few success stories of cancer therapy, most …

The treatment of malignant primary brain tumors is challenging. Concomitant
radiochemotherapy has become the standard clinical treatment for malignant glioma, but …

Cancer has been considered as complex malignant consequence of genetic mutations that
control the cellular proliferation, differentiation and homeostasis, thus making tumor …