Abstract The Ral (Ras‐Like) signaling pathway plays an important role in the biology of
cells. A plethora of effects is regulated by this signaling pathway and its prooncogenic …

Currently, various oncolytic adenoviruses (OA) are being explored in both preclinical and
clinical virotherapy. However, the pre-existing neutralizing antibodies (nAbs) and poor …

Oncolytic virus (OV) therapy utilizes replication-competent viruses to kill cancer cells, leaving
non-malignant cells unharmed. With the first US Food and Drug Administration-approved …

Introduction: Breast cancer is the most common cancer in women all over the world.
Furthermore, up to one third of breast tumors develop metastases that are resistant to …

The viral lytic cycle is an important process in oncolytic virotherapy. Most mathematical
models for oncolytic virotherapy do not incorporate this process. In this article, we propose a …

Breast cancer is the malignant tumour that developed from cells of the breast and is the first
leading cause of cancer death among women worldwide. Surgery, radiotherapy, and …

Oncolytic virotherapy is a promising avenue of cancer gene therapy. Current vectors include
human viruses that have been engineered to replicate in tumor cells or nonhuman viruses …

Virotherapy is not a new concept, but recent technical advances in the genetic modification
of oncolytic viruses have improved their tumor specificity, leading to the development of new …

New cancer therapies with novel mechanisms and functions are needed to treatpatients with
different cancers. Virotherapy is a good scenario for such treatment. The advantages of …

Oncolytic viruses (OVs) are attractive avenues of cancer therapy due to the absence of toxic
side effects often seen with current treatment modalities. Bovine herpesvirus 1 (BHV-1) is a …