The mechanisms by which cells sense their mechanical environment and transduce the
signal through focal adhesions and signaling pathways to the nucleus is an area of key …

Physical properties of tissue are increasingly recognised as major regulatory cues affecting
cell behaviours, particularly cell migration. While these properties of the extracellular matrix …

The aim of this study was to elucidate the mechanism of action of the insulin-like growth
factor 2 mRNA-binding protein 1 (IGF2BP1) on the phenotype of the liver cancer stem cells …

Local adaptation is facilitated by loci clustered in relatively few regions of the genome,
termed genomic islands of divergence. The mechanisms that create and maintain these …

Clinical evidence supports a role for the extracellular matrix (ECM) in cancer plasticity
across multiple tumor types. The lack of in vitro models that represent the native ECMs is a …

The attachment of carbohydrates to other macromolecules, such as proteins or lipids, is an
important regulatory mechanism termed glycosylation. One subtype of protein glycosylation …

Background Changes in protein glycosylation are widely observed in tumor cells. N-glycan
branching through adding β1, 6-linked N-acetylglucosamine (β1, 6-GlcNAc) to an α1, 6 …

The extracellular matrix (ECM) provides structural support for cells and mediates cell-stromal
communications. In addition to ECM proteins, mechanical force exerted from the ECM …

Glioma progression is accompanied with increased tumor tissue stiffness, yet the underlying
mechanisms are unclear. Herein, we employed atomic force microscopy analysis to show …

For many decades, interactions between diffuse lower-grade glioma (LGG) and brain
connectome were neglected. However, the neoplasm progression is intimately linked to its …