Analysis of shared heritability in common disorders of the brain
Brainstorm Consortium, V Anttila, B Bulik-Sullivan… - Science, 2018 - science.org
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …
Anorexia nervosa: aetiology, assessment, and treatment
Anorexia nervosa is an important cause of physical and psychosocial morbidity. Recent
years have brought advances in understanding of the underlying psychobiology that …
years have brought advances in understanding of the underlying psychobiology that …
Constrained maximum likelihood-based Mendelian randomization robust to both correlated and uncorrelated pleiotropic effects
With the increasing availability of large-scale GWAS summary data on various complex traits
and diseases, there have been tremendous interests in applications of Mendelian …
and diseases, there have been tremendous interests in applications of Mendelian …
Comparative genetic architectures of schizophrenia in East Asian and European populations
Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk
globally. Large-scale schizophrenia genetic studies have reported primarily on European …
globally. Large-scale schizophrenia genetic studies have reported primarily on European …
A molecular census of arcuate hypothalamus and median eminence cell types
The hypothalamic arcuate–median eminence complex (Arc-ME) controls energy balance,
fertility and growth through molecularly distinct cell types, many of which remain unknown …
fertility and growth through molecularly distinct cell types, many of which remain unknown …
LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and …
J Zheng, AM Erzurumluoglu, BL Elsworth… - …, 2017 - academic.oup.com
Motivation LD score regression is a reliable and efficient method of using genome-wide
association study (GWAS) summary-level results data to estimate the SNP heritability of …
association study (GWAS) summary-level results data to estimate the SNP heritability of …
An atlas of genetic correlations across human diseases and traits
Identifying genetic correlations between complex traits and diseases can provide useful
etiological insights and help prioritize likely causal relationships. The major challenges …
etiological insights and help prioritize likely causal relationships. The major challenges …
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
Vitamin D is a steroid hormone precursor that is associated with a range of human traits and
diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four …
diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four …
Partitioning heritability by functional annotation using genome-wide association summary statistics
Recent work has demonstrated that some functional categories of the genome contribute
disproportionately to the heritability of complex diseases. Here we analyze a broad set of …
disproportionately to the heritability of complex diseases. Here we analyze a broad set of …
Topologically associating domain boundaries that are stable across diverse cell types are evolutionarily constrained and enriched for heritability
E McArthur, JA Capra - The American Journal of Human Genetics, 2021 - cell.com
Topologically associating domains (TADs) are fundamental units of three-dimensional (3D)
nuclear organization. The regions bordering TADs—TAD boundaries—contribute to the …
nuclear organization. The regions bordering TADs—TAD boundaries—contribute to the …