Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer

A Karlstaedt, J Moslehi, RA de Boer - Nature Reviews Cardiology, 2022 - nature.com
Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in
the world. The emerging field of cardio-oncology has revealed that these seemingly …

Targeting DNA damage response in cardiovascular diseases: from pathophysiology to therapeutic implications

L Wu, JR Sowers, Y Zhang, J Ren - Cardiovascular research, 2023 - academic.oup.com
Cardiovascular diseases (CVDs) arise from a complex interplay among genomic, proteomic,
and metabolomic abnormalities. Emerging evidence has recently consolidated the presence …

Multifactorial diseases of the heart, kidneys, lungs, and liver and incident cancer: epidemiology and shared mechanisms

C Shi, S de Wit, E Učambarlić… - Cancers, 2023 - mdpi.com
Simple Summary Multifactorial diseases are caused by a combination of genetic and
environmental factors and various risk factors that accumulate with age. Cardiovascular …

Clonal haematopoiesis of indeterminate potential: associations with heart failure incidence, clinical parameters and biomarkers

C Shi, JP Aboumsallem, N Suthahar… - European journal of …, 2023 - Wiley Online Library
Aim We aimed to analyse the association of clonal haematopoiesis of indeterminate
potential (CHIP) with incident heart failure (HF) in a European population cohort. Methods …

Priorities in Cardio-Oncology Basic and Translational Science: GCOS 2023 Symposium Proceedings: JACC: CardioOncology State-of-the-Art Review

FN Salloum, CG Tocchetti, P Ameri, H Ardehali… - Cardio Oncology, 2023 - jacc.org
Despite improvements in cancer survival, cancer therapy–related cardiovascular toxicity has
risen to become a prominent clinical challenge. This has led to the growth of the burgeoning …

Small extracellular vesicles from infarcted and failing heart accelerate tumor growth

T Caller, I Rotem, O Shaihov-Teper, D Lendengolts… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Myocardial infarction (MI) and heart failure are associated with an
increased incidence of cancer. However, the mechanism is complex and unclear. Here, we …

Temporal trends in the incidence of malignancy in heart failure: a nationwide Danish study

J Bruhn, M Malmborg, CH Garred, P Ravn… - European heart …, 2023 - academic.oup.com
Aims Cancer and heart failure (HF) share risk factors, pathophysiological mechanisms, and
possibly genetics. Improved HF survival may increase the risk of cancer due to a competing …

The role of cholesterol metabolism in tumor therapy, from bench to bed

W Xia, H Wang, X Zhou, Y Wang, L Xue… - Frontiers in …, 2023 - frontiersin.org
Cholesterol and its metabolites have important biological functions. Cholesterol is able to
maintain the physical properties of cell membrane, play an important role in cellular …

Association between heart failure and the incidence of cancer: a systematic review and meta-analysis

V Jaiswal, SP Ang, V Agrawal… - … Heart Journal Open, 2023 - academic.oup.com
Aims The association between heart failure (HF) patients and the incidence of cancer is not
well understood, with conflicting results to date. The aim of this meta-analysis was to …

Circular RNAs at the intersection of cancer and heart disease: potential therapeutic targets in cardio-oncology

D Neufeldt, S Cushman, C Bär… - Cardiovascular …, 2023 - academic.oup.com
Considerable progress has been made in managing cancer; however, with these
advancements comes the discovery of previously unknown adverse events. In particular, the …