The global prevalence of latent tuberculosis: a systematic review and meta-analysis

A Cohen, VD Mathiasen, T Schön… - European Respiratory …, 2019 - Eur Respiratory Soc
In 1999, the World Health Organization (WHO) estimated that one-third of the world's
population had latent tuberculosis infection (LTBI), which was recently updated to one …

Incipient and subclinical tuberculosis: a clinical review of early stages and progression of infection

PK Drain, KL Bajema, D Dowdy, K Dheda… - Clinical microbiology …, 2018 - Am Soc Microbiol
Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a
limited understanding of its clinical pathogenic spectrum of infection and disease …

The global burden of latent tuberculosis infection: a re-estimation using mathematical modelling

RMGJ Houben, PJ Dodd - PLoS medicine, 2016 - journals.plos.org
Background The existing estimate of the global burden of latent TB infection (LTBI) as “one-
third” of the world population is nearly 20 y old. Given the importance of controlling LTBI as …

Revisiting the timetable of tuberculosis

MA Behr, PH Edelstein, L Ramakrishnan - Bmj, 2018 - bmj.com
Revisiting the timetable of tuberculosis Page 1 Revisiting the timetable of tuberculosis OPEN
ACCESS Tuberculosis has a much shorter incubation period than is widely thought, say Marcel …

[HTML][HTML] The definition of tuberculosis infection based on the spectrum of tuberculosis disease

GB Migliori, CWM Ong, L Petrone, L D'Ambrosio… - Breathe, 2021 - Eur Respiratory Soc
Latent tuberculosis infection was the term traditionally used to indicate tuberculosis (TB)
infection. This term was used to define “a state of persistent immune response to stimulation …

The epidemiological importance of subclinical tuberculosis. A critical reappraisal

EA Kendall, S Shrestha, DW Dowdy - American journal of …, 2021 - atsjournals.org
From Chlamydia (1) to malaria (2) to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2)(3), it is increasingly recognized that individuals without recognizable …

T cells and adaptive immunity to Mycobacterium tuberculosis in humans

LD Jasenosky, TJ Scriba, WA Hanekom… - Immunological …, 2015 - Wiley Online Library
The adaptive immune response mediated by T cells is critical for control of Mycobacterium
tuberculosis (M. tuberculosis) infection in humans. However, the M. tuberculosis antigens …

Mycobacterium tuberculosis Dissemination Plays a Critical Role in Pathogenesis

MG Moule, JD Cirillo - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
Mycobacterium tuberculosis is primarily a respiratory pathogen. However, 15% of infections
worldwide occur at extrapulmonary sites causing additional complications for diagnosis and …

Co‐evolution of Mycobacterium tuberculosis and Homo sapiens

D Brites, S Gagneux - Immunological reviews, 2015 - Wiley Online Library
The causative agent of human tuberculosis (TB), M ycobacterium tuberculosis, is an obligate
pathogen that evolved to exclusively persist in human populations. For M. tuberculosis to …

Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses

A Lenaerts, CE Barry III, V Dartois - Immunological reviews, 2015 - Wiley Online Library
Tuberculosis (TB) lesions are extremely complex and dynamic. Here, we review the multiple
types and fates of pulmonary lesions that form following infection by M ycobacterium …