Implications of peptide assemblies in amyloid diseases

PC Ke, MA Sani, F Ding, A Kakinen, I Javed… - Chemical Society …, 2017 - pubs.rsc.org
Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

Arylglyoxals in synthesis of heterocyclic compounds

B Eftekhari-Sis, M Zirak, A Akbari - Chemical reviews, 2013 - ACS Publications
Heterocycles are an extraordinarily important class of compounds, making up more than half
of all known organic compounds. Heterocycles are present in a wide variety of drugs, most …

A survey of the role of noncovalent sulfur interactions in drug design

BR Beno, KS Yeung, MD Bartberger… - Journal of medicinal …, 2015 - ACS Publications
Electron deficient, bivalent sulfur atoms have two areas of positive electrostatic potential, a
consequence of the low-lying σ* orbitals of the C–S bond that are available for interaction …

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease

J Wagner, S Ryazanov, A Leonov, J Levin, S Shi… - Acta …, 2013 - Springer
In neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD)
and prion diseases, deposits of aggregated disease-specific proteins are found. Oligomeric …

Recent developments of 2-aminothiazoles in medicinal chemistry

D Das, P Sikdar, M Bairagi - European Journal of Medicinal Chemistry, 2016 - Elsevier
Abstract The 2-aminothiazole (2-AT) core is an active pharmacophore and used in medicinal
chemistry and drug discovery research. A number of drugs with 2-AT core are in the market …

Developments towards synthesis of N-heterocycles from amidines via C–N/C–C bond formation

W Guo, M Zhao, W Tan, L Zheng, K Tao… - Organic Chemistry …, 2019 - pubs.rsc.org
The synthesis of N-heterocycles is one of the most active areas due to their structures with
extensive applications in the fields of organic, pharmaceutical and materials chemistry. It is …

Development and therapeutic potential of 2-aminothiazole derivatives in anticancer drug discovery

SR Alizadeh, SM Hashemi - Medicinal Chemistry Research, 2021 - Springer
Currently, the development of anticancer drug resistance is significantly restricted the clinical
efficacy of the most commonly prescribed anticancer drug. Malignant disease is widely …

Drug resistance confounding prion therapeutics

DB Berry, D Lu, M Geva, JC Watts… - Proceedings of the …, 2013 - National Acad Sciences
There is not a single pharmaceutical that halts or even slows any neurodegenerative
disease. Mounting evidence shows that prions cause many neurodegenerative diseases …

Copper-catalyzed coupling of oxime acetates with isothiocyanates: a strategy for 2-aminothiazoles

X Tang, Z Zhu, C Qi, W Wu, H Jiang - Organic letters, 2016 - ACS Publications
A new strategy for 2-aminothiazoles is developed via the copper-catalyzed coupling of
oxime acetates with isothiocyanates. Various 4-substituted and 4, 5-disubstituted 2 …

A retrospect study on thiazole derivatives as the potential antidiabetic agents in drug discovery and developments

GL Khatik, AK Datusalia, W Ahsan… - Current drug …, 2018 - ingentaconnect.com
Background: Heterocycles containing thiazole, a moiety with sulfur and nitrogen is a core
structure which is found in a number of biologically active compounds. The thiazole ring is …