Engineered nanoparticles (NPs) are in the same size category as atmospheric ultrafine
particles,< 100 nm. Per given volume, both have high numbers and surface areas compared …

Highlights•The Biologically Effective Dose (BED) is the mechanistic entity that actually drives
toxicity.•Mechanisms of nanoparticle (NP) toxicity need to be considered in relation to …

Occupational exposure to silica dust has been examined as a possible risk factor with
respect to several systemic autoimmune diseases, including scleroderma, rheumatoid …

Objective Crystalline silica may act as an immune adjuvant to increase inflammation and
antibody production, and findings of occupational cohort studies suggest that silica exposure …

The majority of collagen in the extracellular matrix is found in a fibrillar form, with long
slender filaments each displaying a characteristic∼ 67 nm D-repeat. Here they provide the …

Autoimmune diseases are pathologic conditions defined by abnormal autoimmune
responses and characterized by immune system reactivity in the form of autoantibodies and …

Anti–neutrophil cytoplasmic autoantibodies (ANCA) are associated with a category of small-
vessel vasculitis (SVV) with frequent glomerulonephritis. The goal of this study was to …

The genetic backgrounds of lupus-prone murine models are a valuable resource for
studying the influence of environmental exposure on autoimmune diseases in sensitive …

The spectrum of ultrastructural appearances assumed by collagen in normal and
pathological tissues is illustrated using techniques of thin section transmission electron …

To determine whether the clinical, immunological and serological features of patients with
silica‐associated systemic sclerosis are different from patients with the 'idiopathic'form of …