The role of Cyclin Dependent Kinase Inhibitor 3 (CDKN3) in promoting human tumors: Literature review and pan-cancer analysis

C Zhang, Q Shen, M Gao, J Li, B Pang - Heliyon, 2024 - cell.com
Background Although many experiments and clinical studies have proved the link between
the expression of CDKN3 and human tumors, we have not been able to identify any …

Multi-omics data analysis identifies prognostic biomarkers across cancers

E Demir Karaman, Z Işık - Medical Sciences, 2023 - mdpi.com
Combining omics data from different layers using integrative methods provides a better
understanding of the biology of a complex disease such as cancer. The discovery of …

[HTML][HTML] GID2 interacts with CDKN3 and regulates pancreatic cancer growth and apoptosis

X Deng, J Ma, W Zhou, Y Yuan, B Wang, X Meng - Laboratory Investigation, 2023 - Elsevier
Dysregulation of deubiquitinase or ubiquitinase-mediated protein expression contributes to
various diseases, including cancer. In the present study, we identified GID2, a subunit of the …

Characterization of breast cancer tumors in older patients who show de novo resistance to endocrine therapy

Y Ishizuka, Y Horimoto, M Yuan, Y Ueki, H Onagi… - Scientific Reports, 2024 - nature.com
The standard treatment for hormone receptor-positive breast cancer in good general
condition is curative surgery followed by endocrine therapy. However, for older patients …

Identification of CDKN3 overexpression as a marker of poor prognosis and potential therapeutic target in low-grade glioma

H Cheng, X Meng, Y Zhang, P Wang, Y Lu - Scientific Reports, 2025 - nature.com
Low-grade glioma (LGG) is a primary, slow-growing brain tumor; however, its treatment and
prognosis remain challenging. In this study, we analyzed cancer data from the TCGA …

The systematic analysis of genes related to butyrate metabolism suggests that CDKN3 could serve as a promising therapeutic target for lung adenocarcinoma …

Y Luan, C Liang, Q Han, X Zhou, N Yang, li Zhao - BMC cancer, 2025 - Springer
Background Metabolic pathways are known to significantly impact the development and
advancement of lung cancer. This study sought to establish a signature related to butyrate …

CDKN3 overcomes bladder cancer cisplatin resistance via LDHA-dependent glycolysis reprogramming

M Li, N Che, Y Jin, J Li, W Yang - OncoTargets and therapy, 2022 - Taylor & Francis
Background Aerobic glycolysis plays an important role in bladder cancer (BLCA)
progression and chemoresistance. Cyclin-dependent kinase inhibitor-3 (CDKN3), a dual …

Identification of Potential Biomarkers Using Integrative Approach: A Case Study of ESCC

M Saikia, DK Bhattacharyya, JK Kalita - SN Computer Science, 2022 - Springer
This paper presents a consensus-based approach that incorporates three microarray and
three RNA-Seq methods for unbiased and integrative identification of differentially …