Abstract P-glycoprotein (P-gp) is a member of ATP-binding cassette (ABC) superfamily
which extrudes chemotherapeutic agents out of the cell. Suppression of this efflux activity …

With the discovery of P-glycoprotein (P-gp), it became evident that ABC-transporters play a
vital role in bioavailability and toxicity of drugs. They prevent intracellular accumulation of …

(1) Background: Drug repositioning is an unconventional drug discovery approach to
explore new therapeutic benefits of existing drugs. Currently, it emerges as a rapid avenue …

Palladium-catalyzed Suzuki–Miyaura cross-coupling of primary benzamides enabled by a
merger of site-selective N, N-di-Boc-activation and cooperative catalysis via N–C bond …

Among the family of nitrogen-containing heterocycles, quinoxalinone (or quinoxalin-2-one)
core, characterized by pyrazin-2 (1H)-one fused to benzene ring at two adjacent carbon …

Two new series of hybrid structures 16a-f and 19a-f containing 1, 2, 4-triazole moiety,
pyrazole core with COX-2 pharmacophore and oxime as NO donor moiety were designed …

A general Negishi acylation of primary amides enabled by a combination of site-selective N,
N-di-Boc activation and nickel catalysis is reported for the first time. The reaction is promoted …

The first Negishi cross‐coupling of amides for the synthesis of versatile diaryl ketones by
selective C− N bond activation under exceedingly mild conditions is reported. The cross …

A method was developed for ketone synthesis via a photoredox‐assisted reductive acyl
cross‐coupling (PARAC) using a nickel/photoredox dual‐catalyzed cross‐electrophile …

P-glycoprotein (Pgp) is one of the most biomedically relevant transporters in the ATP binding
cassette (ABC) superfamily due to its involvement in developing multidrug resistance in …