Colorectal cancer, the fourth leading cause of cancer-related death worldwide, is a
multifactorial disease involving genetic, environmental and lifestyle risk factors. In addition …

Pore-forming toxins (PFTs) are the most common bacterial cytotoxic proteins and are
required for virulence in a large number of important pathogens, including Streptococcus …

Background Based on recent research reports, dysbiosis and improper concentrations of
microbial metabolites in the gut may result into the carcinogenesis of colorectal cancer …

Colorectal cancer (CRC) is the third most common newly diagnosed cancer in both men and
women in the Unites States. Colonoscopy has become increasingly popular in CRC …

Clostridia produce the highest number of toxins of any type of bacteria and are involved in
severe diseases in humans and other animals. Most of the clostridial toxins are pore-forming …

We report development of a genetic system for making targeted gene knockouts in
Clostridium thermocellum, a thermophilic anaerobic bacterium that rapidly solubilizes …

Sophisticated genetic tools to modify essential biological processes at the molecular level
are pivotal in elucidating the molecular pathogenesis of Clostridium difficile, a major cause …

The Clostridium perfringens necrotic enteritis B-like toxin (NetB) is a recently discovered
member of the β-barrel pore-forming toxin family and is produced by a subset of avian C …

Isolation of Clostridium mutants based on gene replacement via allelic exchange remains a
major limitation for this important genus. Use of a heterologous counterselection marker can …

Pore-forming toxins (PFTs) are the most common class of bacterial protein toxin and are
important for bacterial pathogenesis. Recent studies have shown that the previous model …