Loss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by
chromosome 3p deletions are detected in almost 100% of small (SCLCs) and more than …

Cancer cells commonly exhibit various forms of genetic instability, such as changes in
chromosome copy number, translocations and point mutations in particular genes. Although …

Conditions that partially inhibit DNA replication induce expression of common fragile sites.
These sites form gaps and breaks on metaphase chromosomes and are deleted and …

HIT (histidine triad) proteins, named for a motif related to the sequence HϕHϕHϕϕ (ϕ, a
hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases …

Forkhead Box P1 (FOXP1) is a member of the FOX family of transcription factors which have
a broad range of functions. Foxp1 is widely expressed and has been shown to have a role in …

In 1979, the first chromosome alteration associated with familial cancer was reported. Five
years later, a fragile site was observed in the same chromosome region. The product of the …

Loss of expression of the Fhit protein is often associated with the development of many
human epithelial cancers, including lung and cervical carcinomas. Restoration of Fhit …

Mice carrying one inactivated Fhit allele (Fhit+/− mice) are highly susceptible to tumor
induction by N-nitrosomethylbenzylamine, with 100% of Fhit+/− mice exhibiting tumors of the …

Chromosomal abnormalities, including homozygous deletions and loss of heterozygosity,
are among the most common features of human tumours. The short arm of human …

Common fragile sites (CFSs) are large genomic regions present in all individuals that are
highly unstable and prone to breakage and rearrangement, especially in cancer cells with …