Pharmaceutical strategies of improving oral systemic bioavailability of curcumin for clinical application

Z Ma, N Wang, H He, X Tang - Journal of Controlled Release, 2019 - Elsevier
Curcumin (Cur), a natural compound from Curcuma longa Linn, has various of
pharmacological activities such as anti-cancer, anti-inflammatory, anti-oxidant, anti …

Pharmaceutical cocrystals: walking the talk

G Bolla, A Nangia - Chemical communications, 2016 - pubs.rsc.org
Pharmaceutical cocrystals belong to a sub-class of cocrystals wherein one of the
components is a drug molecule (or an active pharmaceutical ingredient, API) and the …

Deep eutectic solvents: Recent advances in fabrication approaches and pharmaceutical applications

Y Liu, Y Wu, J Liu, W Wang, Q Yang, G Yang - International Journal of …, 2022 - Elsevier
Deep eutectic solvents (DESs) have received increasing attention in the past decade owing
to their distinguished properties including biocompatibility, tunability, thermal and chemical …

Engineering cocrystals of poorly water-soluble drugs to enhance dissolution in aqueous medium

I Sathisaran, SV Dalvi - Pharmaceutics, 2018 - mdpi.com
Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor
aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and …

Eutectic mixtures as an approach to enhance solubility, dissolution rate and oral bioavailability of poorly water-soluble drugs

GC Bazzo, BR Pezzini, HK Stulzer - International Journal of Pharmaceutics, 2020 - Elsevier
Eutectic mixtures have been known for a long time in the pharmaceutical field. However, its
potential as a system to improve the solubility and dissolution of poorly water-soluble drugs …

Polymorphism in cocrystals: a review and assessment of its significance

S Aitipamula, PS Chow, RBH Tan - CrystEngComm, 2014 - pubs.rsc.org
Cocrystals have gained much interest in recent years owing to their potential to improve the
physicochemical properties of the parent compounds. It was once thought that cocrystals …

Eutectics as improved pharmaceutical materials: design, properties and characterization

S Cherukuvada, A Nangia - Chemical Communications, 2014 - pubs.rsc.org
Eutectics are a long known class of multi-component solids with important and useful
applications in daily life. In comparison to other multi-component crystalline solids, such as …

Curcumin, a promising anti-cancer therapeutic: a review of its chemical properties, bioactivity and approaches to cancer cell delivery

M Salem, S Rohani, ER Gillies - RSC advances, 2014 - pubs.rsc.org
The development of new anti-cancer treatments with greater efficacy and fewer side effects
remains a significant challenge of modern scientific and medical research. Curcumin, a …

Deep eutectic solvents comprising active pharmaceutical ingredients in the development of drug delivery systems

SN Pedro, MG Freire, CSR Freire… - Expert opinion on drug …, 2019 - Taylor & Francis
Introduction: Deep eutectic solvents comprising or acting as solvents of active
pharmaceutical ingredients (API-DES) emerged as promising alternatives to improve …

Impact of curcumin nanoformulation on its antimicrobial activity

AC da Silva, PD de Freitas Santos… - Trends in Food Science …, 2018 - Elsevier
Background Curcumin is a yellow-orange, hydrophobic compound extracted from Curcuma
longa and widely used by oriental cultures. It displays numerous biological activities and …